Non-linear response and viscoelastic properties of lipid-coated microbubbles: DSPC versus DPPC.

Ultrasound in Medicine & Biology
Tom van RooijKlazina Kooiman

Abstract

For successful in vivo contrast-enhanced ultrasound imaging (CEUS) and ultrasound molecular imaging, detailed knowledge of stability and acoustical properties of the microbubbles is essential. Here, we compare these aspects of lipid-coated microbubbles that have either 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) or 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) as their main lipid; the other components were identical. The microbubbles were investigated in vitro over the frequency range 1-4 MHz at pressures between 10 and 100 kPa, and their response to the applied ultrasound was recorded using ultrahigh-speed imaging (15 Mfps). Relative to DPPC-coated microbubbles, DSPC-coated microbubbles had (i) higher acoustical stability; (ii) higher shell elasticity as derived using the Marmottant model (DSPC: 0.26 ± 0.13 N/m, DPPC: 0.06 ± 0.06 N/m); (iii) pressure amplitudes twice as high at the second harmonic frequency; and (iv) a smaller amount of microbubbles that responded at the subharmonic frequency. Because of their higher acoustical stability and higher non-linear response, DSPC-coated microbubbles may be more suitable for contrast-enhanced ultrasound.

References

Dec 1, 1986·Physics in Medicine and Biology·H C StarrittV F Humphrey
May 20, 1998·Ultrasound in Medicine & Biology·P M ShankarV L Newhouse
Jun 1, 2000·Ultrasonics·N de JongF J Ten Cate
May 23, 2002·Echocardiography·Nico de JongPeter Frinking
Aug 3, 2002·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·James ChomasKatherine Ferrara
Apr 13, 2004·Investigative Radiology·Alexander L KlibanovGary H Brandenburger
Jul 21, 2004·Colloids and Surfaces. B, Biointerfaces·Mark A BordenMarjorie L Longo
Sep 29, 2004·Colloids and Surfaces. B, Biointerfaces·Patrycja Dynarowicz-Łatka, Katarzyna Hac-Wydro
Jan 21, 2006·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Mark A BordenKatherine W Ferrara
Apr 19, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Mark A BordenKatherine W Ferrara
Feb 15, 2007·The Journal of the Acoustical Society of America·Sander M van der MeerDetlef Lohse
Feb 27, 2007·Ultrasound in Medicine & Biology·Nico de JongMichel Versluis
May 25, 2007·Ultrasound in Medicine & Biology·David E GoertzAntonius F W van der Steen
Nov 21, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexander L Klibanov
Feb 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·S KrishnanM O'Donnell
May 3, 2008·Ultrasound in Medicine & Biology·Benjamin DolletMichel Versluis
Jul 5, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Kevin ChettyRobert J Eckersley
Feb 12, 2009·Medical & Biological Engineering & Computing·David Cosgrove, Chris Harvey
Aug 27, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Monica M Lozano, Marjorie L Longo
Nov 19, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Steven B FeinsteinKai Thomenius
Nov 28, 2009·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Marcia EmmerNico de Jong
Dec 17, 2009·The Journal of the Acoustical Society of America·Juan TuThomas J Matula
Feb 18, 2010·JACC. Cardiovascular Imaging·Jonathan R Lindner
Feb 25, 2010·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Paul L M J van NeerNico de Jong
Jun 15, 2010·Clinical Radiology·N DeshpandeJ K Willmann
Oct 30, 2010·Ultrasound in Medicine & Biology·Marlies OverveldeMichel Versluis
Nov 30, 2010·The Journal of the Acoustical Society of America·Jeroen SijlMichel Versluis
Jan 25, 2011·Ultrasound in Medicine & Biology·Telli FaezNico De Jong
Apr 12, 2011·The Journal of the Acoustical Society of America·Jeroen SijlMichel Versluis
May 3, 2011·Ultrasound in Medicine & Biology·Telli FaezNico de Jong
May 24, 2011·Ultrasound in Medicine & Biology·Hendrik J VosNico de Jong
Aug 6, 2011·Ultrasound in Medicine & Biology·Marlies OverveldeMichel Versluis
Nov 7, 2012·The Review of Scientific Instruments·Erik C GelderblomMichel Versluis
Dec 1, 2012·Ultrasound in Medicine & Biology·Ying LuanNico de Jong
Feb 1, 2013·The Journal of the Acoustical Society of America·Brandon L Helfield, David E Goertz
Mar 5, 2013·Ultrasound in Medicine & Biology·Chung-Hsin Wang, Chih-Kuang Yeh
May 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Neveen A HosnyMarina K Kuimova
Jul 31, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Yogi KurniawanGeoffrey D Bothun
Nov 23, 2013·Ultrasound in Medicine & Biology·Jason L RaymondChristy K Holland
Nov 26, 2013·Advanced Drug Delivery Reviews·I LentackerC T W Moonen
Mar 13, 2014·Physics in Medicine and Biology·Brandon L HelfieldDavid E Goertz

❮ Previous
Next ❯

Citations

Feb 13, 2016·Biomicrofluidics·Guillaume LajoinieMichel Versluis
Jan 16, 2016·Therapeutic Delivery·Roberta CavalliMonica Argenziano
Feb 2, 2016·The Journal of the Acoustical Society of America·Brandon HelfieldFlordeliza S Villanueva
Jul 30, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tom van RooijKlazina Kooiman
Aug 24, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Jordan S LumMark A Borden
Jan 24, 2017·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Verya DaeichinKlazina Kooiman
Mar 14, 2017·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Tom van RooijKlazina Kooiman
Nov 12, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hongbo LiDong Zhang
Nov 5, 2016·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Helen MulvanaEleanor Stride
Jul 11, 2019·Scientific Reports·Himanshu ShekharChristy K Holland
Jun 4, 2020·The Journal of the Acoustical Society of America·Outi SupponenMark Borden
Jan 23, 2021·Pharmaceutics·Simone A G LangeveldKlazina Kooiman
Mar 1, 2021·The Journal of the Acoustical Society of America·Georges ChabouhGwennou Coupier
Nov 28, 2017·Ultrasound in Medicine & Biology·Himanshu ShekharChristy K Holland
Jun 12, 2021·Ultrasound in Medicine & Biology·Rajarshi ChattarajChandra M Sehgal
Aug 17, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Hiraku TabataMarie Pierre Krafft
Sep 14, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Miles AronEleanor Stride
Mar 2, 2018·ACS Applied Materials & Interfaces·Christopher HernandezAgata A Exner
Feb 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Simone A G LangeveldKlazina Kooiman
Jan 18, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Silke RooversIne Lentacker
Oct 1, 2020·International Journal of Pharmaceutics·Tamotsu MaruyamaRyo Suzuki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.