Jan 29, 2016

Non-linear tumor-immune interactions arising from spatial metabolic heterogeneity

BioRxiv : the Preprint Server for Biology
Mark Robertson-TessiAlexander RA Anderson

Abstract

A hybrid multiscale mathematical model of tumor growth is used to investigate how tumoral and microenvironmental heterogeneity affect the response of the immune system. The model includes vascular dynamics and evolution of metabolic tumor phenotypes. Cytotoxic T cells are simulated, and their effect on tumor growth is shown to be dependent on the structure of the microenvironment and the distribution of tumor phenotypes. Importantly, no single immune strategy is best at all stages of tumor growth.

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Mentioned in this Paper

Spatial Memory
Metabolic Process, Cellular
Immune System
Tumor Immunity
Blood Vessel
Spatial Distribution
Cytotoxic T-Lymphocytes
Neoplasms
Structure
Tumor Growth

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