Nov 16, 2006

Non-low-density lipoprotein cholesterol-associated actions of ezetimibe: an overview

Expert Opinion on Therapeutic Targets
Irene Gazi, Dimitri P Mikhailidis


Ezetimibe, an intestinal cholesterol absorption inhibitor, lowers circulating low-density lipoprotein cholesterol (LDL-C) levels both when administered as monotherapy and in combination with other hypolipidaemic drugs, mostly statins. This review focuses on the effects of ezetimibe on non-LDL-C-associated variables. In most studies, ezetimibe effectively reduced triglyceride and increased high density lipoprotein cholesterol levels. The authors also consider the effect of ezetimibe on other variables such as C-reactive protein levels, insulin sensitivity and endothelial function. Ezetimibe is useful in patients with sitosterolaemia (a rare inherited disorder) as it significantly reduces plasma phytosterol concentrations. Ezetimibe fulfils two of the three essential characteristics of any drug (efficacy and safety). However, clinical studies are required to provide evidence of its ability to reduce vascular events.

Mentioned in this Paper

Insulin Sensitivity
C-reactive Protein Measurement
Blood Vessel
Hypolipidemic Agents
Antilipemic agent
High Density Lipoprotein Measurement
High Density Lipoprotein Cholesterol

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