Non-maturational covariates for dynamic systems pharmacology models in neonates, infants, and children: Filling the gaps beyond developmental pharmacology

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Karel AllegaertJohn N van den Anker

Abstract

Pharmacokinetics and -dynamics show important changes throughout childhood. Studies on the different maturational processes that influence developmental pharmacology have been used to create population PK/PD models that can yield individualized pediatric drug dosages. These models were subsequently translated to semi-physiologically or physiology-based PK (PBPK) models that support predictions in pediatric patient cohorts and other special populations. Although these translational efforts are crucial, these models should be further improved towards individual patient predictions by including knowledge on non-maturational covariates. These efforts are needed to ultimately get to systems pharmacology models for children. These models take developmental changes relating to the pediatric dynamical system into account but also other aspects that may be of importance such as abnormal body composition, pharmacogenetics, critical illness and inflammatory status.

Citations

Feb 10, 2018·Expert Review of Clinical Pharmacology·Karel AllegaertJohn N van den Anker
Feb 9, 2018·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Genny RaffaeliEnno D Wildschut
Jun 5, 2019·International Journal of Molecular Sciences·Fiona O'BrienCatherine Tuleu
Oct 29, 2019·British Journal of Clinical Pharmacology·Maarja HallikTuuli Metsvaht
Dec 22, 2019·Clinical Pharmacology and Therapeutics·Sebastiaan C GouloozeCatherijne A J Knibbe
Jul 24, 2020·Clinical and Translational Science·Bianca D van GroenLoeckie de Zwart
Feb 12, 2019·Expert Review of Clinical Pharmacology·Karel AllegaertJohn Van Den Anker
Sep 4, 2018·Pharmaceutical Medicine·Kristine Svinning ValeurKarel Allegaert
Sep 11, 2019·Journal of Clinical Pharmacology·Karel Allegaert, John van den Anker
Jan 25, 2018·Expert Opinion on Drug Metabolism & Toxicology·Tamara Van DongeKarel Allegaert
Jan 6, 2021·Pharmaceutics·Miriam AyusoSteven Van Cruchten
Jun 30, 2021·Journal of Clinical Pharmacology·John van den Anker, Karel Allegaert

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