Non-medical Cannabis Self-Exposure as a Dimensional Predictor of Opioid Dependence Diagnosis: A Propensity Score Matched Analysis

Frontiers in Psychiatry
Eduardo R ButelmanMary Jeanne Kreek

Abstract

Background: The impact of increasing non-medical cannabis use on vulnerability to develop opioid use disorders has received considerable attention, with contrasting findings. A dimensional analysis of self-exposure to cannabis and other drugs, in individuals with and without opioid dependence (OD) diagnoses, may clarify this issue. Objective: To examine the age of onset of maximal self-exposure to cannabis, alcohol, cocaine, and heroin, in volunteers diagnosed with OD, using a rapidly administered instrument (the KMSK scales). To then determine whether maximal self-exposure to cannabis, alcohol, and cocaine is a dimensional predictor of odds of OD diagnoses. Methods: This outpatient observational study examined maximal self-exposure to these drugs, in volunteers diagnosed with DSM-IV OD or other drug diagnoses, and normal volunteers. In order to focus more directly on opioid dependence diagnosis as the outcome, volunteers who had cocaine dependence diagnoses were excluded. Male and female adults of diverse ethnicity were consecutively ascertained from the community, and from local drug treatment programs, in 2002-2013 (n = 574, of whom n = 94 had OD diagnoses). The age of onset of maximal self-exposure of these drugs was examin...Continue Reading

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Citations

Mar 19, 2019·Neuropharmacology·Megan J Moerke, S Stevens Negus
Sep 2, 2020·Pharmacology, Biochemistry, and Behavior·Kyle A Windisch, Mary Jeanne Kreek
Apr 9, 2021·Peptides·Richard J Bodnar
Jul 4, 2021·Drug and Alcohol Dependence·Eduardo R ButelmanMary Jeanne Kreek

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Software Mentioned

R
KMSK
GraphPad Prism
Statistica ( TIBCO )
MatchIt

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