PMID: 11931229Apr 5, 2002Paper

Non-Mendelian inheritance and homology-dependent effects in ciliates

Advances in Genetics
Eric Meyer, Olivier Garnier

Abstract

Ciliates are single-celled eukaryotes that harbor two kinds of nuclei. The germline micronuclei function only to perpetuate the genome during sexual reproduction; the macronuclei are polyploid, somatic nuclei that differentiate from the micronuclear lineage at each sexual generation. Macronuclear development involves extensive and reproducible rearrangements of the genome, including chromosome fragmentation and precise excision of numerous internal sequence elements. In Paramecium and Tetrahymena, homology-dependent maternal effects have been evidenced by transformation of the vegetative macronucleus with germline sequences containing internal eliminated sequences (short single-copy elements), which can result in a specific inhibition of the excision of the homologous elements during development of a new macronucleus in the sexual progeny of transformed clones. Furthermore, transformation of the Paramecium maternal macronucleus with cloned macronuclear sequences can specifically induce new fragmentation patterns or internal deletions in the zygotic macronucleus. These experiments show that the processing of many germline sequences in the developing macronucleus is sensitive to the presence and copy number of homologous sequence...Continue Reading

Citations

Jul 27, 2002·Annual Review of Microbiology·Carolyn L Jahn, Lawrence A Klobutcher
Oct 1, 2003·Molecular and Cellular Biology·Ariane Gratias, Mireille Bétermier
Nov 29, 2002·Eukaryotic Cell·Linda SperlingJean Cohen
Aug 18, 2004·Molecular and Cellular Biology·Olivier GarnierEric Meyer
Jan 5, 2005·Nature Reviews. Genetics·Marjori A Matzke, James A Birchler
Jan 25, 2006·Molecular Biology and Evolution·Li Chin Wong, Laura F Landweber
Aug 2, 2011·Annual Review of Genomics and Human Genetics·Mariusz NowackiLaura F Landweber
May 9, 2014·Nature·Deepankar Pratap SinghEric Meyer
Apr 7, 2005·Médecine sciences : M/S·Eric Meyer, Janine Beisson
Feb 13, 2003·Eukaryotic Cell·Mary Ellen JacobsLawrence A Klobutcher
Jun 5, 2008·PloS One·Matthias MöllenbeckLaura F Landweber
Jul 14, 2014·Nucleic Acids Research·Estienne C SwartMariusz Nowacki
Dec 15, 2020·Genome Biology and Evolution·Natalia Sawka-GądekEric Meyer
Oct 26, 2005·Current Biology : CB·Douglas L Chalker

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