Non-Mendelian transmission of alleles at microsatellite loci: an example in Ixodes ricinus, the vector of Lyme disease

International Journal for Parasitology
T De MeeûsFrançois Renaud

Abstract

Microsatellite loci are usually considered to be neutral co-dominant and Mendelian markers. We undertook to study the inheritance of five microsatellite loci in the European Lyme disease vector, the tick Ixodes ricinus. Only two loci appeared fully Mendelian while the three others displayed non-Mendelian patterns that highly frequent null alleles could not fully explain. At one locus, IR27, some phenomenon seems to hinder the PCR amplification of one allele, depending on its origin (maternal imprinting) and/or its size (short allele dominance). DNA methylation, which appeared to be a possible explanation of this amplification bias, was rejected by a specific test comparing the amplification efficiency that did not differ between unmethylated and experimentally methylated DNA. The role of allele size in heterozygous individuals was then revealed from the data available on field collected ticks and consistent with the results of a theoretical approach. These observations highlight the need for prudence while inferring reproductive systems (selfing rates), parentage or even allelic frequencies from microsatellite markers, in particular for parasitic organisms for which molecular approaches often represent the only way for populati...Continue Reading

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Citations

Mar 18, 2009·PLoS Neglected Tropical Diseases·Philippe SolanoThierry De Meeûs
Jun 6, 2009·Journal of Medical Entomology·Florent KempfKaren D McCoy
Jul 6, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Florent KempfThierry De Meeûs
Nov 18, 2005·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Thierry De MeeûsFrançois Balloux
Apr 29, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tanekou Tito Trésor MélachioThierry De Meeûs
Sep 4, 2007·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Thierry de Meeûs, Jérôme Goudet
Oct 11, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Florent KempfKaren D McCoy
May 2, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Thierry De MeeûsPhilippe Solano
Sep 9, 2018·Molecular Biology Reports·T Olivier AmoussouAboubacar Toguyéni
Sep 23, 2018·Ticks and Tick-borne Diseases·K HuberC Chevillon
Aug 8, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·S RavelP Solano
Jan 12, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Jérémy BouyerThierry De Meeûs

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