Non-metastatic prostate cancer: rationale for conservative treatment and impact on disease-related morbidity and mortality in the elderly.

Scandinavian Journal of Urology
Sven LöffelerErik Skaaheim Haug

Abstract

Purpose: To determine the rationale for not offering local treatment to prostate cancer patients with non-metastatic disease at diagnosis who later died of prostate cancer and to document local and systemic complications caused by disease progression.Material and Methods: In this population-based, retrospective study we reviewed the medical records of all patients who died of prostate cancer in 2009-2014 in Vestfold County (Vestfold Mortality Study), who were non-metastatic at diagnosis and who had received no local treatment to the prostate (n = 117).Results: A review of patient records demonstrated that the chronological age of 75 years or older was the main rationale for not offering local treatment to the prostate (37%, n = 43). No consideration was given to the functional status and patient health. These elderly patients stood for almost one-fifth of the total PC mortality in Vestfold County. In addition to dying from PC, 86% of patients developed local complications attributable to PC progression. Observation of strict limits for local treatment with regard to tumor characteristics contributed further to the underuse of local treatment.Conclusions: Our study demonstrated systematic undertreatment of elderly patients with ...Continue Reading

References

Dec 1, 1982·American Journal of Clinical Oncology·M M OkenP P Carbone
Oct 9, 2007·European Urology·Axel HeidenreichUNKNOWN European Association of Urology
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Taofeek K OwonikokoSuresh S Ramalingam
Dec 12, 2012·The New England Journal of Medicine·Charles J RyanUNKNOWN COU-AA-302 Investigators
Mar 7, 2014·The New England Journal of Medicine·Anna Bill-AxelsonJan-Erik Johansson
Jun 3, 2014·The New England Journal of Medicine·Tomasz M BeerUNKNOWN PREVAIL Investigators
Nov 10, 2015·Obstetrics and Gynecology·J Alejandro Rauh-HainMarcela G Del Carmen
Jul 13, 2017·The New England Journal of Medicine·Timothy J WiltMichael K Brawer
Nov 22, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A PetterssonP Stattin
Jan 13, 2018·Scandinavian Journal of Urology·Sven LöffelerErik Skaaheim Haug

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