Non-metastatic stage IV nasopharyngeal carcinoma patients: analysis of the pattern of relapse and survival

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
E OzyarI L Atahan

Abstract

The objective of this study is to analyze the mode of recurrence patterns and survival of our 96 non-metastatic stage IVA and IVB nasopharyngeal carcinoma (NPC) patients. A total of 234 previously untreated, histologically confirmed non-metastatic NPC patients were treated in our department between 1993 and 2001. Among them 96 patients (41%) were staged as IVA or B disease. All patients were uniformly staged using the fifth edition of AJCC/UICC staging system. There were 76 male and 20 female patients. Their ages ranged from 9 to 72 years (median age: 43.5). Histopathological diagnosis was WHO 2 and 3 in 89 (93%) patients. All patients were treated with external radiotherapy and 77 out of 96 patients (80%) with stage IV disease received either concomitant or neoadjuvant cisplatin based combined chemotherapy regimens. Median follow-up time was 30 months (range: 4-101 months). At the time of this analysis, 60 (62%) patients were alive and 48 of them were free of disease. Local recurrence rate was found to be significantly higher in stage IVA patients (28 vs. 11%, P=0.02) and distant metastasis rate was significantly higher in stage IVB patients (40 vs. %8, P=0.0001). The 3 year overall (OS), disease free (DFS), loco regional rela...Continue Reading

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Citations

May 20, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Lei ZengTai-Xiang Lu
Sep 19, 2006·International Journal of Radiation Oncology, Biology, Physics·Skye Hongiun ChengAndrew T Huang
Apr 22, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Peter M L TeoAnthony T C Chan
Apr 22, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Jin-Cheng LuMing Ni
Oct 26, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Ching-Yeh HsiungHoward I Amols
Sep 13, 2005·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Enis OzyarI Lale Atahan
Nov 19, 2013·Current Problems in Cancer·Virag DandekarPaul M Kent
Apr 12, 2011·Acta Oto-laryngologica·Senem DemirciMustafa Esassolak

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