Abstract
Many human autoimmune diseases, including those of the thyroid gland, are affected by immune changes during pregnancy and the postpartum period. To investigate this influence, we have developed an animal model of pregnancy thyroiditis by using thyroglobulin (Tg)-induced experimental autoimmune thyroiditis (EAT). We now report a study of the post-partum period in mice with EAT. At 5 weeks postpartum, which was 9 weeks after the completion of a Tg immunization regime, the mean thyroiditis grade was significantly increased in the postpartum group from 0.23 to 0.43 (p<0.05) and the thyroiditis Index, which reflected both the frequency and severity of thyroiditis, was similarly increased compared to controls (29.0 vs 9.0). When Tg immunized CBA/J (H-2k) female mice were mated with BALB/c (H-2d) males, there was a similar increase in the severity of thyroiditis in the postpartum period as seen with CBA/J males suggesting that allogeneic factors were not able to further this postpartum exacerbation. Spleen cell IL-4 secretion was enhanced in the postpartum but only in the presence of thyroiditis indicating enhanced activity of Th2 immune responses. There were no differences in IFN-gamma secretion, titers of anti-Tg, CD8+ & CD4+ T cell...Continue Reading
References
May 1, 1977·The Journal of Experimental Medicine·P S EsquivelY C Kong
May 1, 1991·Experimental and Clinical Endocrinology·S MariottiA Pinchera
Jan 1, 1992·Diabetes·N F BernardH Margolese
Jul 21, 1988·Nature·T L StevensE S Vitetta
Aug 1, 1985·Cellular Immunology·L L SimonY M Kong
Sep 1, 1983·Annales d'immunologie·C Buffet-JanvresseA G Hovanessian
Oct 1, 1994·Clinical and Experimental Immunology·E ChronopoulouG Carayanniotis
Jan 1, 1994·Autoimmunity·R W McMurrayH Braley-Mullen
Mar 1, 1995·European Journal of Immunology·T GermannE Rüde
Jan 1, 1995·Immunology Today·R S LiblauH O McDevitt
Aug 12, 1993·The New England Journal of Medicine·J L NelsonJ A Hansen
Sep 1, 1993·Human Genetics·T T HsiehS M Kao
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W BianchiM A DeMaria
Apr 1, 1996·Thyroid : Official Journal of the American Thyroid Association·M HeuerW A Scherbaum
Sep 1, 1996·Clinical and Experimental Immunology·R A AjjanA P Weetman
May 1, 1997·American Journal of Reproductive Immunology : AJRI·M WatanabeN Amino
Nov 14, 1997·Immunology Today·R Raghupathy
Feb 5, 1998·Nature·P LoetscherJ M Dayer
Feb 12, 1998·The New England Journal of Medicine·A D Luster
Mar 3, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M KühnertE Halberstadt
Mar 11, 1998·Lancet·J L NelsonD W Bianchi
Apr 29, 1998·Nature·M Baggiolini
Jun 30, 1998·American Journal of Reproductive Immunology : AJRI·L MatthiesenJ Ernerudh
Jul 31, 1998·The New England Journal of Medicine·C ConfavreuxT Moreau
Jul 7, 1999·The Journal of Clinical Investigation·M MuraiK Matsushima
Aug 5, 1999·Autoimmunity·J GuoS M McLachlan
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·A P Weetman
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·T F Davies
Sep 10, 1999·Journal of Dairy Science·K A Shafer-WeaverL M Sordillo
Feb 13, 2001·Endocrinology·M ImaizumiT Davies
Citations
Nov 12, 2003·Current Rheumatology Reports·Ann M Reed
Nov 12, 2003·Current Rheumatology Reports·Ann M Reed
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Takao Ando, Terry F Davies
Aug 19, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naoko ArataTerry F Davies
Jul 27, 2011·Journal of Autoimmunity·Melissa A Landek-SalgadoPatrizio Caturegli
May 14, 2016·Journal of Assisted Reproduction and Genetics·Frances Grimstad, Sacha Krieg
Apr 28, 2010·Nature Reviews. Endocrinology·Anthony P Weetman
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Takao AndoTerry F Davies
Dec 26, 2001·Endocrinology·M ImaizumiT F Davies