Non-MHC driven exacerbation of experimental thyroiditis in the postpartum period

Autoimmunity
M ImaizumiT F Davies

Abstract

Many human autoimmune diseases, including those of the thyroid gland, are affected by immune changes during pregnancy and the postpartum period. To investigate this influence, we have developed an animal model of pregnancy thyroiditis by using thyroglobulin (Tg)-induced experimental autoimmune thyroiditis (EAT). We now report a study of the post-partum period in mice with EAT. At 5 weeks postpartum, which was 9 weeks after the completion of a Tg immunization regime, the mean thyroiditis grade was significantly increased in the postpartum group from 0.23 to 0.43 (p<0.05) and the thyroiditis Index, which reflected both the frequency and severity of thyroiditis, was similarly increased compared to controls (29.0 vs 9.0). When Tg immunized CBA/J (H-2k) female mice were mated with BALB/c (H-2d) males, there was a similar increase in the severity of thyroiditis in the postpartum period as seen with CBA/J males suggesting that allogeneic factors were not able to further this postpartum exacerbation. Spleen cell IL-4 secretion was enhanced in the postpartum but only in the presence of thyroiditis indicating enhanced activity of Th2 immune responses. There were no differences in IFN-gamma secretion, titers of anti-Tg, CD8+ & CD4+ T cell...Continue Reading

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Citations

Nov 12, 2003·Current Rheumatology Reports·Ann M Reed
Nov 12, 2003·Current Rheumatology Reports·Ann M Reed
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Takao Ando, Terry F Davies
Aug 19, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Naoko ArataTerry F Davies
Jul 27, 2011·Journal of Autoimmunity·Melissa A Landek-SalgadoPatrizio Caturegli
May 14, 2016·Journal of Assisted Reproduction and Genetics·Frances Grimstad, Sacha Krieg
Apr 28, 2010·Nature Reviews. Endocrinology·Anthony P Weetman
Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Takao AndoTerry F Davies
Dec 26, 2001·Endocrinology·M ImaizumiT F Davies

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