Non-mix fragrances are top sensitizers in consecutive dermatitis patients - a cross-sectional study of the 26 EU-labelled fragrance allergens

Contact Dermatitis
N H BennikeJeanne Duus Johansen

Abstract

For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene (Lim-OOH)] and oxidized linalool [hydroperoxides of linalool (Lin-OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients. To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II. A cross-sectional study on consecutive dermatitis patients patch tested with the 26 fragrances and the European baseline series from 2010 to 2015 at a single university clinic was performed. Of 6004 patients, 940 (15.7%, 95%CI: 14.7-16.6%) were fragrance-sensitized. Regarding the single fragrances, most patients were sensitized to Lin-OOH (3.9%), Evernia furfuracea (3.0%), Lim-OOH (2.5%), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (2.1%). Significantly fewer patients were 'FM I-positive and constituent-positive' than 'FM II-positive and constituent-positive' (32.7% versus 57.0%, p < 0.0001). Additionally, significantly more patients were 'FM II-negative but constituent-positive' than 'FM I-negative but...Continue Reading

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Citations

Mar 30, 2018·The British Journal of Dermatology·Wolfgang Uter
Jun 27, 2018·Contact Dermatitis·Fátima Tous-RomeroJavier Ortiz de Frutos
Nov 14, 2018·Contact Dermatitis·Mark WilkinsonWolfgang Uter
Nov 16, 2018·Contact Dermatitis·Juan F SilvestreVirginia Fernández-Redondo
Oct 30, 2018·Contact Dermatitis·Farzad AlinaghiJeanne D Johansen
May 31, 2019·Current Opinion in Allergy and Clinical Immunology·Jeanne D Johansen, Thomas Werfel
Jul 10, 2019·Contact Dermatitis·Evy Paulsen, Flemming Andersen
Apr 9, 2019·Contact Dermatitis·Ryan J SchutteStanislav Vukmanović
Jan 19, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·A E Goossens
Jul 18, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anton de Groot
Jul 9, 2020·Contact Dermatitis·Lina HagvallAnn-Therese Karlberg
Aug 28, 2020·Contact Dermatitis·Emma HortonMark Wilkinson
Aug 11, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·N H BennikeJ D Johansen
Apr 1, 2018·Contact Dermatitis·Lina HagvallAnn-Therese Karlberg
Aug 23, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anton C de Groot
May 31, 2018·International Journal of Environmental Research and Public Health·Wolfgang UterJeanne D Johansen
May 29, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Pierre Nanyan
Dec 2, 2017·Contact Dermatitis·Mark WilkinsonWolfgang Uter
Apr 9, 2020·Dermatitis : Contact, Atopic, Occupational, Drug·Magnus BruzeUNKNOWN International Contact Dermatitis Research Group
Aug 23, 2019·Dermatitis : Contact, Atopic, Occupational, Drug·Anton de Groot
Oct 20, 2020·Contact Dermatitis·Thanisorn SukakulWaranya Boonchai
Sep 12, 2020·The Australasian Journal of Dermatology·Kate DearRosemary Louise Nixon

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