Non-mono-exponential attenuation of water and N-acetyl aspartate signals due to diffusion in brain tissue

Journal of Magnetic Resonance
Yaniv Assaf, Yoram Cohen

Abstract

Diffusion measurements were performed on water and N-acetyl aspartate (NAA) molecules in excised brain tissue using a wide range of b-values (up to 28.3 x 10(6) and 35.8 x 10(6) s cm-2 for water and NAA, respectively). The attenuation of the signals of water and NAA due to diffusion was measured at fixed diffusion times (tD). These measurements, in which the echo time (TE) was set to 70 ms, were repeated for several diffusion times ranging from 35 to 305 ms. Signal attenuations were fitted to mono-, bi-, and triexponential functions to obtain the apparent diffusion coefficients (ADCs) of these molecules at each diffusion time. From these experiments the following observations and conclusions were made: (1) Signal attenuation of water and NAA due to diffusion over the entire range of b values examined is not monoexponential and the extracted ADCs depend on the diffusion time; (2) In the case of water the experimental data are best fitted by a triexponential function, while for b values up to 1 x 10(6) s cm-2, a biexponential function seems to reproduce the experimental data as well as the triexponential function; (3) If only the low range of b values are fitted (up to 0.5 x 10(6) s cm-2) signal attenuation of water is monoexpone...Continue Reading

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Citations

Jun 6, 2013·Neural Plasticity·Lin JiangChunshui Yu
Jan 22, 2013·Molecular Neurodegeneration·Takuya HayashiHirotaka Onoe
Mar 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jiangyang ZhangPeter A Calabresi
Sep 10, 2003·Journal of Neurosurgery·T P Dóczi, A Schwarcz
Dec 25, 2009·Radiology·Bachir Taouli, Dow-Mu Koh
Sep 23, 2006·Radiology·Anita RamaniJoseph A Helpern
Jun 28, 2011·NeuroImage·Els FieremansJoseph A Helpern
Nov 29, 2007·IEEE Transactions on Medical Imaging·Sharon Peled
Sep 26, 2008·IEEE Transactions on Medical Imaging·Chun-Hung YehChing-Po Lin
Jun 11, 2008·IEEE Transactions on Medical Imaging·Yu-Chien WuAndrew L Alexander
Mar 31, 2006·Journal of Magnetic Resonance·Carin MalmborgDaniel Topgaard
May 8, 2007·NeuroImage·Yu-Chien Wu, Andrew L Alexander
Oct 12, 2011·NeuroImage·Denis Le Bihan
May 25, 2011·AJR. American Journal of Roentgenology·Dirk BlondinHans-Jörg Wittsack
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Jan 28, 2015·Medical Image Analysis·A Pasha HosseinborAndrew L Alexander
Jan 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y AssafY Cohen
Jun 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M D Does, J C Gore
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Mar 1, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Chih-Liang ChinDavid B Hackney
Oct 3, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dmitriy A YablonskiyJoseph J H Ackerman
Feb 3, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Attila SchwarczJean-Claude Beloeil
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yaniv AssafYoram Cohen
Dec 19, 2017·Journal of Magnetic Resonance Imaging : JMRI·Yu-Kun SongJian-Ping Chu
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Elisabeth A H von dem Hagen, R Mark Henkelman

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