Non-motor manifestations in ALS patients with tracheostomy and invasive ventilation

Muscle & Nerve
Yuki NakayamaEiji Isozaki

Abstract

This study aimed to investigate non-motor manifestations in amyotrophic lateral sclerosis (ALS) patients with tracheostomy and invasive ventilation (TIV) and their relevance to disease progression. Sixty-seven ALS patients with TIV were enrolled, and followed-up prospectively. The patients were classified at the final evaluation into two subgroups according to the duration of TIV use or disease stage measured by communication impairment. We identified non-motor manifestations and investigated their frequencies and differences across the stages. The non-motor manifestations were macroglossia (22.4%), unstable blood pressure (38.8%), hypothermia (26.9%), dysuria (50.7%), and hyperglycemia (12.1%). These manifestations occurred significantly more frequently in patients with TIV ≥5 years than in patients with TIV <5 years, and more in patients with severe communication impairment than in those with preserved communication ability. Non-motor manifestations are observed at a high rate in ALS patients with TIV, and are possibly related to disease progression. Muscle Nerve 57: 735-741, 2018.

References

Sep 1, 1991·Journal of the Neurological Sciences·H HayashiA Kawada
Oct 1, 1989·Journal of the Neurological Sciences·H Hayashi, S Kato
Jan 1, 1987·Auris, Nasus, Larynx·M Mizuno, M Yamane
Jun 1, 1994·Journal of the Neurological Sciences·T ShimizuM Oda
Apr 6, 2000·Neurology·T ShimizuM Oda
Jul 24, 2001·Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases·B R BrooksUNKNOWN World Federation of Neurology Research Group on Motor Neuron Diseases
Jun 26, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·M BeckM Naumann
May 20, 2003·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M KarlsborgJ Mehlsen
Jul 9, 2003·Neurology·Hideaki Hayashi, Edward Anthony Oppenheimer
Sep 13, 2005·Current Opinion in Neurology·Rositsa BaltadzhievaAmos D Korczyn
Feb 20, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masashi HamadaYoshikazu Ugawa
Sep 14, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Tomoyo HayashiShigeki Kuzuhara
Oct 31, 2008·Journal of the Neurological Sciences·Naoki AtsutaUNKNOWN Research Committee on the Neurodegenerative Diseases of Japan
Feb 27, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Pierre-Francois PradatVincent Meininger
Aug 26, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Kazumasa ShindoYoshihisa Takiyama
Dec 4, 2010·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Toshio ShimizuHideaki Hayashi
Apr 22, 2011·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Maria Laura Lopes de CarvalhoGiampaolo Brichetto
Jul 13, 2011·Archives of Neurology·Rakesh SharmaMartin R Turner
Oct 25, 2011·Rinshō shinkeigaku = Clinical neurology·Tsuyoshi MatsumuraSaburo Sakoda
Jul 28, 2012·Annals of Rehabilitation Medicine·Ha Lim Lee, Ju Kang Lee
Sep 20, 2012·Journal of the Neurological Sciences·Rossella SpataroVincenzo La Bella
Sep 18, 2013·JAMA Neurology·Heather R McKeeEdward Kasarskis
Sep 27, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Pia DreyerMichael Felding
Nov 13, 2013·Nature Reviews. Neurology·Heiko BraakKelly Del Tredici
Feb 1, 2014·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Georg S NüblingAndrea S Winkler
Jul 16, 2014·Journal of the Neurological Sciences·Muneyoshi TagamiToshiaki Hanafusa
Jun 5, 2015·Clinical Neuropathology·Kiyomitsu OyanagiTakashi Komori
Jun 30, 2015·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Yuki NakayamaImaharu Nakano
Jan 28, 2016·Muscle & Nerve·Chiharu MatsudaMasanobu Kinoshita

❮ Previous
Next ❯

Citations

Nov 21, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Jul 17, 2019·The International Journal of Neuroscience·Min Cheol Chang, Soyoung Kwak
Jan 16, 2020·Journal of Neurology, Neurosurgery, and Psychiatry·Naoki HayashiGen Sobue
Aug 31, 2018·Neurology Research International·Osama A Khairoalsindi, Ahmad R Abuzinadah
Apr 8, 2020·Molecular Syndromology·Şule AltınerAlper H Çebi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.