PMID: 9447237Feb 3, 1998Paper

Non-native architectures in protein design and mimicry

Cellular and Molecular Life Sciences : CMLS
M Mutter, G Tuchscherer

Abstract

Protein design aims to mimic some of the structural and functional properties of native proteins. The complexity of the folding mechanism, i.e. the pathway by which a linear polypeptide chain finds its unique 3D-structure, represents one of the most intriguing hurdles in this rapidly growing field. In order to bypass this well-known protein-folding problem, some years ago we proposed the construction of non-native chain architectures with a high propensity for folding. According to this concept, termed TASP (template-assembled synthetic proteins), topological templates are used as a built-in device for directing covalently attached peptide blocks to a predetermined packing arrangement, resulting in branched chain architectures. Recent progress in the synthetic methodology for assembling peptides now allows us to access the full potential of the TASP concept. In this article, we discuss the state of the art of template-based protein de novo design, with special emphasis on progress in peptide synthesis and template design and show that some fundamental questions in protein assembly, structure and function can be approached by designing protein mimetics of reduced structural and functional complexity.

Citations

Aug 15, 1998·Biopolymers·M GoodmanE Locardi
May 24, 2000·Journal of Peptide Science : an Official Publication of the European Peptide Society·M N MathieuG W Tregear
Apr 12, 2001·Journal of Peptide Science : an Official Publication of the European Peptide Society·D GrellM Mutter
Sep 12, 2001·Current Opinion in Biotechnology·L Baltzer, J Nilsson
Sep 27, 2002·Current Opinion in Biotechnology·Ulf ReimerJens Schneider-Mergener
Feb 27, 1999·Current Opinion in Biotechnology·H Bayley
Oct 6, 2000·Journal of Molecular Graphics & Modelling·D GrellM Mutter
May 20, 1999·Journal of Biomolecular Structure & Dynamics·D Di MaroN Niccolai
Mar 26, 2014·Chemical Reviews·Fangting YuVincent L Pecoraro
Nov 5, 1999·Journal of Molecular Biology·P Koehl, M Levitt
Jun 10, 2011·Current Opinion in Biotechnology·Dhiraj BhatiaYamuna Krishnan
Jun 3, 2004·Chembiochem : a European Journal of Chemical Biology·Jacques HauertTibor Kovacsovics
Aug 8, 2006·Chembiochem : a European Journal of Chemical Biology·Yashveer SinghPascal Dumy
Nov 22, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Didier BoturynPascal Dumy
Oct 20, 2005·Magnetic Resonance in Chemistry : MRC·Christian F W BeckerMartin Engelhard
Oct 20, 1999·Methods : a Companion to Methods in Enzymology·M Sakarellos-DaitsiotisC Sakarellos
May 27, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Marta CalPiotr Stefanowicz
Jun 25, 2016·Chemical Society Reviews·Flavia NastriAngela Lombardi
Aug 12, 1999·Journal of Peptide Science : an Official Publication of the European Peptide Society·F PeriM Mutter
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viktorija HercegNorbert Lange
Oct 12, 1999·The Journal of Peptide Research : Official Journal of the American Peptide Society·G TuchschererM Mutter
Mar 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jalal BacharoucheGrégory Francius
Jul 5, 2007·Organic & Biomolecular Chemistry·A Pernille ToftengKnud J Jensen
Jan 14, 2020·Journal of Inorganic Biochemistry·Monica PerinelliMaurizio Remelli
Jan 23, 2009·Bioconjugate Chemistry·Neeraj ChopraStephen C Meredith
Nov 17, 2001·Chemical Reviews·L BaltzerJ Nilsson
Nov 20, 2003·Journal of the American Chemical Society·Baohua HuangJon R Parquette
Nov 4, 2004·Journal of the American Chemical Society·Robert SchnepfPeter Hildebrandt
Jul 17, 2003·Journal of the American Chemical Society·Kirsten LeufgenUNKNOWN TOF-SIMS Study
Jul 18, 2001·Journal of the American Chemical Society·R SchnepfW Haehnel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.