Non-native glyceraldehyde-3-phosphate dehydrogenase can be an intrinsic component of amyloid structures

Biochimica Et Biophysica Acta
Irina NaletovaVladimir I Muronetz

Abstract

Interactions between different forms of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and amyloid-beta peptide (1-42) were investigated by direct (surface plasmon resonance) and indirect (kinetics of spontaneous and GroEL/S-assisted reactivation of denatured GAPDH) methods. It was demonstrated that non-native forms of GAPDH obtained by different ways (cold denaturation, oxidation of the enzyme, and its unfolding in guanidine hydrochloride) efficiently bind to soluble amyloid-beta peptide (1-42) yielding a stable complex. Native tetrameric GAPDH does not interact with soluble amyloid-beta peptide (1-42), neither non-native forms of GAPDH interact with aggregated amyloid-beta peptide (1-42). The results suggest that non-native GAPDH species can be involved in the formation of amyloid structures during Alzheimer's disease, binding to soluble amyloid-beta peptide (1-42).

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Citations

Sep 13, 2012·Neuroscience Bulletin·Xue-Mei GuZhao-Feng Jiang
Feb 6, 2013·Biochemistry. Biokhimii︠a︡·E I ArutyunovaV I Muronetz
Jun 15, 2011·BMC Evolutionary Biology·Mikhail L KuravskyVladimir I Muronetz
Dec 7, 2013·Neurochemical Research·Saadia ZahidNikhat Ahmed
Sep 24, 2014·Pathologie-biologie·N El KadmiriA Soukri
Jul 16, 2014·Journal of Molecular Neuroscience : MN·Nadia El KadmiriAbdelaziz Soukri
Jan 10, 2016·Free Radical Biology & Medicine·Vladimir F LazarevBoris A Margulis
Nov 4, 2010·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Florian M GebhardtPeter R Dodd
Mar 23, 2012·Journal of Neurochemistry·Saadia ZahidNikhat Ahmed
Dec 18, 2009·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
May 25, 2016·International Journal of Biological Macromolecules·Vladimir I MuronetzElena V Schmalhausen
Jan 15, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nadia El KadmiriAbdelaziz Soukri
Feb 16, 2016·Biochemistry. Biokhimii︠a︡·V I MuronetzE V Schmalhausen
May 7, 2020·Pharmaceutics·Vladimir F LazarevBoris A Margulis
Jun 1, 2018·Current Medicinal Chemistry·Vladimir I MuronetzElena V Schmalhausen
Sep 15, 2017·Biophysics Reviews·César L AvilaRosana Chehín

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