Non-NMDA receptors modulate respiratory drive in fetal sheep

The Journal of Physiology
J M BissonnetteS J Knopp

Abstract

1. Experiments were carried out in unanaesthetized fetal sheep to evaluate the significance of non-N-methyl-D-aspartate (non-NMDA) receptor neurotransmission in the expression of fetal breathing movements. Catheters placed in the trachea and amniotic fluid and electrodes beneath the parietal bones and in the nuchal muscle were used to monitor breath amplitude and frequency and fetal behavioural state. 2. Experiments were carried out by instillation of neurotransmitter agonists, antagonists or receptor modulators into the cerebrospinal fluid (CSF) of the fourth ventricle by means of a chronic catheter introduced through the foramen magnum. 3. The non-NMDA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) decreased respiratory rate in a dose dependent manner by lengthening both inspiratory time (T1) and expiratory time (T0). 4. Kainate and (R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) increased breath amplitude. Instillation of the antagonist 2,3-dihydro-6-nitro-7-sulphamoyl-benzo(f) quinoxaline (NBQX) prior to administering AMPA resulted in apnoea, which was not overcome by the agonist. 5. Cyclothiazide, which has been shown to prevent desensitization of AMPA receptors, caused an increase in...Continue Reading

References

Aug 1, 1990·American Journal of Obstetrics and Gynecology·O S BamfordC E Blanco
Aug 1, 1990·Pediatric Research·J M BissonnetteN F Notoroberto
Aug 1, 1989·Neuron·L O Trussell, G D Fischbach
Jan 1, 1972·The Journal of Physiology·G S DawesR T Richards
May 1, 1994·Respiration Physiology·J M BissonnetteS J Knopp
Sep 15, 1995·The Journal of Physiology·J M BissonnetteS J Knopp

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Citations

Apr 17, 2002·The Journal of Physiology·R J A WilsonJ E Remmers
Nov 26, 2015·Respiratory Physiology & Neurobiology·Dirk HeitzmannJoerg Thomas
Mar 11, 2010·Respiratory Physiology & Neurobiology·John M BissonnetteSharon J Knopp
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G M WhitneyD Gozal
Jun 10, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J M Bissonnette

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