Non-Nutrient, Naturally Occurring Phenolic Compounds with Antioxidant Activity for the Prevention and Treatment of Periodontal Diseases

Antioxidants
Alfonso Varela-LópezJosè L Quiles

Abstract

One of the main factors able to explain the pathophysiological mechanism of inflammatory conditions that occur in periodontal disease is oxidative stress. Given the emerging understanding of this relationship, host-modulatory therapies using antioxidants could be interesting to prevent or slow the breakdown of soft and hard periodontal tissues. In this context, non-nutrient phenolic compounds of various foods and plants have received considerable attention in the last decade. Here, studies focusing on the relationship between different compounds of this type with periodontal disease have been collected. Among them, thymoquinone, coenzyme Q (CoQ), mangiferin, resveratrol, verbascoside and some flavonoids have shown to prevent or ameliorate periodontal tissues damage in animal models. However evidence regarding this effect in humans is poor and only limited to topical treatments with CoQ and catechins. Along with animal experiments, in vitro studies indicate that possible mechanisms by which these compounds might exert their protective effects include antioxidative properties, oxygen and nitrogen scavenging abilities, and also inhibitory effects on cell signaling cascades related to inflammatory processes which have an effect on ...Continue Reading

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Citations

Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Varela-LópezJosé L Quiles
Jul 28, 2016·International Journal of Molecular Sciences·Alfonso Varela-LópezJosé L Quiles
Sep 13, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Varela-LópezJosé L Quiles
Jan 18, 2020·Journal of Periodontology·Ahmed A AlhassaniKaumudi J Joshipura
Nov 15, 2016·Oxidative Medicine and Cellular Longevity·Chong ZhaoYoshinori Katakura
Sep 1, 2017·Annals of the New York Academy of Sciences·Yu-Tang ChinLeroy F Liu
May 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Varela-LópezJosé L Quiles
Dec 17, 2020·Antioxidants·Mohamed MekhemarChristof Dörfer
Apr 12, 2019·Archives of Oral Biology·Alejandro I Lorenzo-PousoYago Leira

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Methods Mentioned

BETA
nuclear translocation

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