Non-nutritive sweeteners: evidence for benefit vs. risk

Current Opinion in Lipidology
Christopher Gardner

Abstract

Intake of added sugars in the American diet is high and has been linked to weight gain and adverse effects on glycemic control and diabetes. Several national health organizations recommend decreasing added sugars intake. Among the many strategies to consider to achieve this reduction is substitution with non-nutritive sweeteners (NNS - artificial sweeteners and stevia). The purpose of this review is to critically examine existing evidence for this strategy. Short-term intervention studies suggest that NNS, when substituted for added sugars, may be useful in supporting energy intake reduction, and promoting glycemic control and weight management. However, the magnitude of effect in these studies has ranged from modest to null. Compensatory eating behaviors likely diminish, and in some cases negate, potential effects. Findings from longer-term observational studies that examine associations between NNS use and obesity or type 2 diabetes are potentially confounded by reverse causality. Existing data are insufficient to clearly support or refute the effectiveness of substitution with NNS as a means of reducing added sugar intake. It is important to not lose sight of the impact of incorporating NNS-containing beverages and foods on ...Continue Reading

References

Jun 1, 1990·The American Journal of Clinical Nutrition·G A ColditzF E Speizer
Oct 1, 1988·Diabetic Medicine : a Journal of the British Diabetic Association·P L CooperR W Simpson
Dec 4, 2003·Journal of the American Dietetic Association·V Lee GrotzF Xavier Pi-Sunyer
Aug 26, 2004·JAMA : the Journal of the American Medical Association·Matthias B SchulzeFrank B Hu
Jul 4, 2007·Pediatrics·Steven M Donn, Gary McAbee
Jun 17, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K C MakiS M Tarka
Dec 6, 2008·The American Journal of Clinical Nutrition·Richard D Mattes, Barry M Popkin
Apr 10, 2009·The New England Journal of Medicine·Kelly D Brownell, Thomas R Frieden
Aug 26, 2009·Circulation·Rachel K JohnsonUNKNOWN American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity, and Metabolism and the Counci
Oct 30, 2009·The American Journal of Clinical Nutrition·Michelle S VanselowSusan K Raatz
Feb 9, 2010·Physiology & Behavior·Frank B Hu, Vasanti S Malik
Mar 25, 2011·The American Journal of Clinical Nutrition·Lawrence de KoningFrank B Hu
Jun 24, 2011·The New England Journal of Medicine·Dariush MozaffarianFrank B Hu
Feb 3, 2012·Nature·Robert H LustigClaire D Brindis
Jun 20, 2012·Journal of the Academy of Nutrition and Dietetics·Cindy FitchUNKNOWN Academy of Nutrition and Dietetics
Jul 11, 2012·Circulation·Christopher GardnerUNKNOWN American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Art

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Citations

Sep 15, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·P J RogersD J Mela
Dec 21, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Sarah S GulRichard A Hodin
Dec 14, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S L TeyC G Forde
Feb 10, 2017·Journal of Food Science·Janaína Madruga Morais FerreiraHelena Maria André Bolini
Aug 24, 2016·Circulation·Miriam B VosUNKNOWN American Heart Association Nutrition Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Clinical C
Nov 20, 2019·Current Atherosclerosis Reports·Yoona KimPeter M Clifton
Nov 27, 2015·The American Journal of Clinical Nutrition·Paul M WiseGary K Beauchamp
Dec 3, 2016·Acta Oto-laryngologica·Orhan OzturanYavuz Selim Yildirim
Jul 27, 2021·BMJ Nutrition, Prevention & Health·Mie NormandAnne Raben
Nov 30, 2021·Nutrition and Health·Regis C PearsonNathan T Jenkins

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