Non-obstructive high-risk plaques increase the risk of future culprit lesions comparable to obstructive plaques without high-risk features: the ICONIC study.

European Heart Journal Cardiovascular Imaging
Richard A FerraroFay Y Lin

Abstract

High-risk plaque (HRP) and non-obstructive coronary artery disease independently predict adverse events, but their importance to future culprit lesions has not been resolved. We sought to determine in patients prior to confirmed acute coronary syndrome (ACS) the association between lesion percent diameter stenosis (%DS), and the absolute number and prevalence of HRP. The secondary objective was to examine the relative importance of non-obstructive HRP in future culprit lesions. Within the ICONIC study, a nested case-control study of patients undergoing coronary computed tomographic angiography (coronary CT), we included ACS cases with culprit lesions confirmed by invasive coronary angiography and coregistered to baseline coronary CT. Quantitative CT was used to evaluate obstructive (≥50%) and non-obstructive (<50%) diameter stenosis, with HRP defined as ≥2 features of spotty calcification, positive remodelling, or low-attenuation plaque at baseline. A total of 234 patients with downstream ACS over 54 (interquartile range 5-525.5) days exhibited 198/898 plaques with HRP on coronary CT. While HRP was less prevalent in non-obstructive (19.7%, 161/819) than obstructive lesions (46.8%, 37/79, P < 0.001), non-obstructive plaque compr...Continue Reading

References

Jul 1, 1988·Journal of the American College of Cardiology·J A AmbroseV Fuster
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R VirmaniS M Schwartz
Jun 27, 2009·Journal of the American College of Cardiology·Sadako MotoyamaJagat Narula
Oct 12, 2010·International Journal of Epidemiology·Shanthi MendisUNKNOWN Writing group on behalf of the participating experts of the WHO consultation for revision of WHO definition of myocardial in
Jan 21, 2011·The New England Journal of Medicine·Gregg W StoneUNKNOWN PROSPECT Investigators
Sep 11, 2012·Journal of the American College of Cardiology·Kristian ThygesenDaniel R Wagner
Dec 15, 2012·JACC. Cardiovascular Imaging·Pál Maurovich-HorvatUdo Hoffmann
Apr 13, 2013·Atherosclerosis·Alessandro MaurielloSara Casella
Aug 16, 2014·Journal of the American College of Cardiology·Jinwei TianIk-Kyung Jang
Nov 5, 2014·JAMA : the Journal of the American Medical Association·Thomas M MaddoxJohn S Rumsfeld
Jun 2, 2018·Journal of the American College of Cardiology·Hyuk-Jae ChangJames K Min
Aug 28, 2018·The New England Journal of Medicine·UNKNOWN SCOT-HEART InvestigatorsMichelle C Williams
Jan 27, 2019·Journal of the American College of Cardiology·Michelle C WilliamsEdward D Nicol
Oct 19, 2019·Journal of the American College of Cardiology·Philip D AdamsonUNKNOWN SCOT-HEART Investigators

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Citations

Jun 15, 2020·European Heart Journal Cardiovascular Imaging·Trisha Singh, David E Newby
Jan 4, 2021·European Heart Journal·José Luis ZamoranoChiara Bucciarelli-Ducci
Jan 22, 2021·Circulation Research·Matthew NayorRamachandran S Vasan
Jul 19, 2021·JACC. Cardiovascular Imaging·Kristian A ØvrehusBjarne L Nørgaard
Aug 27, 2021·Journal of Cardiovascular Development and Disease·Gudrun FeuchtnerFabian Barbieri
Sep 1, 2021·European Heart Journal Cardiovascular Imaging·Thor EdvardsenBernard Cosyns

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