Non-oncogenic roles of TAp73: from multiciliogenesis to metabolism.

Cell Death and Differentiation
Alice NemajerovaUte M Moll

Abstract

The p53 family of transcription factors (p53, p63 and p73) covers a wide range of functions critical for development, homeostasis and health of mammals across their lifespan. Beside the well-established tumor suppressor role, recent evidence has highlighted novel non-oncogenic functions exerted by p73. In particular, p73 is required for multiciliated cell (MCC) differentiation; MCCs have critical roles in brain and airways to move fluids across epithelial surfaces and to transport germ cells in the reproductive tract. This novel function of p73 provides a unifying cellular mechanism for the disparate inflammatory and immunological phenotypes of p73-deficient mice. Indeed, mice with Trp73 deficiency suffer from hydrocephalus, sterility and chronic respiratory tract infections due to profound defects in ciliogenesis and complete loss of mucociliary clearance since MCCs are essential for cleaning airways from inhaled pollutants, pathogens and allergens. Cross-species genomic analyses and functional rescue experiments identify TAp73 as the master transcriptional integrator of ciliogenesis, upstream of previously known central nodes. In addition, TAp73 shows a significant ability to regulate cellular metabolism and energy production...Continue Reading

References

Nov 6, 1998·The Journal of Experimental Medicine·V De LaurenziG Melino
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·K HibiD Sidransky
Jun 30, 2000·Biochemical and Biophysical Research Communications·V De LaurenziG Melino
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yingjian YouSteven L Brody
Nov 24, 2006·Nature·Eun-Kyung SuhFrank McKeon
Oct 24, 2007·Nature Reviews. Molecular Cell Biology·Manfred FliegaufHeymut Omran
Apr 15, 2008·Trends in Cell Biology·Richard TomasiniGerry Melino
Sep 23, 2008·Genes & Development·Richard TomasiniTak W Mak
Jan 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard TomasiniTak W Mak
Apr 7, 2009·Cell·Maddalena AdornoStefano Piccolo
Jul 3, 2009·Cell Stem Cell·Xiaohua SuElsa R Flores
Sep 19, 2009·Cell Death and Differentiation·D CoutandinV Dötsch
Oct 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Andreas C JoergerAlan R Fersht
Nov 17, 2009·Cell·Erich A Nigg, Jordan W Raff
Jan 13, 2010·Cell·Patricia A J MullerKaren H Vousden
May 21, 2010·The Journal of Clinical Investigation·Alice NemajerovaUte M Moll
Jun 8, 2010·American Journal of Respiratory Cell and Molecular Biology·Anna DvorakRonald G Crystal
Oct 28, 2010·Biochemical and Biophysical Research Communications·Massimiliano AgostiniGerry Melino
Nov 16, 2010·Current Biology : CB·Masashi FujitaniDavid R Kaplan
Mar 24, 2011·Nature Reviews. Molecular Cell Biology·Arnold J LevineGerry Melino
Jul 16, 2011·Cell Death and Differentiation·G Melino
Aug 2, 2011·Nature Genetics·Jason W LocasaleMatthew G Vander Heiden
Aug 23, 2011·PloS One·Márcia M AranhaCecília M P Rodrigues
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Massimiliano AgostiniGerry Melino
Dec 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Massimiliano AgostiniGerry Melino
Mar 16, 2012·Cell Death & Disease·F ConfortiB S Sayan
Apr 14, 2012·Leukemia & Lymphoma·Evguenia M Alexandrova, Ute M Moll
Sep 19, 2012·Genes & Development·Alessandro RufiniTak Wah Mak
Nov 20, 2012·Cell Cycle·Francesca GrespiGerry Melino
Mar 26, 2013·Methods in Enzymology·Eszter K Vladar, Steven L Brody
Mar 30, 2013·Cell Death and Differentiation·L M LuhV Dötsch
Jul 3, 2013·Nature Cell Biology·Wenjing DuXiaolu Yang
Nov 5, 2013·Oncogene·I AmelioG Melino
Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Satoshi InoueTak W Mak

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Citations

Mar 9, 2018·International Journal of Molecular Sciences·Yoko Itahana, Koji Itahana
May 10, 2019·Molecular Oncology·Balasubramanian ChandramouliGiovanni Chillemi
Aug 17, 2019·Cell Cycle·Caterina LannaLuca Bianchi
Jun 26, 2020·Cell Cycle·Niall BuckleyGerry Melino
Jul 15, 2020·International Journal of Molecular Sciences·Maria Victoria Niklison-ChirouGerry Melino
Dec 12, 2018·Aging·Piervito LoprioreIvano Amelio
Nov 11, 2017·Cell Death and Differentiation·Francesca Pentimalli
Jun 27, 2018·Proceedings of the National Academy of Sciences of the United States of America·Marco PieraccioliGerry Melino
Mar 30, 2019·Journal of Molecular Cell Biology·Arnold J Levine
Aug 17, 2020·Nucleic Acids Research·Morgan A SammonsMartin Fischer
Mar 21, 2020·Cell Death Discovery·Massimiliano AgostiniGerry Melino
Apr 2, 2019·Frontiers in Genetics·Margarita M MarquesMaria C Marin
Jul 17, 2019·Cell Death & Disease·Elham AlsahafiMahvash Tavassoli
Feb 23, 2020·International Journal of Molecular Sciences·Chao WangKanaga Sabapathy
Mar 29, 2020·Cell Death Discovery·Ivano Amelio, Gerry Melino
Jun 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ivano AmelioGerry Melino
May 5, 2020·Seminars in Cell & Developmental Biology·Michael Lewis, Travis H Stracker
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jakob GebelVolker Dötsch
Dec 11, 2020·Cell Death Discovery·Alessio ButeraGerry Melino
Oct 16, 2020·Biology Direct·Ivano AmelioGerry Melino
Nov 18, 2020·Biochemistry. Biokhimii︠a︡·G Melino
Nov 21, 2020·Biology Direct·Ivana CelardoIvano Amelio
May 1, 2019·Current Medicinal Chemistry·José M MatésJavier Márquez

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Methods Mentioned

BETA
scanning microscopy
RNA-seq
immunoprecipitation

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