PMID: 8938535Nov 1, 1996Paper

Non-organ specific autoantibodies in children with chronic hepatitis C

Journal of Hepatology
Flavia BortolottiF B Bianchi

Abstract

Recent studies in adult patients have established a relationship between hepatitis C virus infection and the presence of liver-kidney microsomal autoantibody type 1 (LKM1). Conversely, little is known regarding the relationship between hepatitis C and autoimmunity in children. In this study, we investigated non-organ specific autoantibodies in 40 otherwise healthy Italian children with chronic hepatitis C. All but four patients included in the study were asymptomatic. Liver histology, obtained in 35, showed features ranging from minimal to mild chronic hepatitis. Autoantibodies were investigated by indirect immunofluorescence. HCV RNA was assayed by the polymerase chain reaction in 34 cases and viral genotypes were determined. Antinuclear antibodies were detected in three (7.5%) cases, one with a homogeneous pattern; smooth muscle autoantibodies in seven (17.5%) cases, always with V (vessels only) specificity and LKM1 in four (10%), at titers ranging from 1:20 and 1:2560. Clinical and virologic features did not significantly differ between autoantibody positive and negative cases, although infections with HCV genotypes 1a and 2 were more frequent in LKM1-positive patients. During observation, the child with the highest LKM1 tit...Continue Reading

References

Sep 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F LunelJ M Huraux
Oct 1, 1991·The Journal of Clinical Investigation·M P MannsE F Johnson
Aug 5, 1989·Lancet·J I EstebanM Buti
Nov 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C HombergP Grippon
Aug 1, 1994·Seminars in Liver Disease·G Mieli-Vergani, D Vergani
Aug 1, 1994·Journal of Hepatology·M GerottoF B Baralle
Jun 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·V J DesmetP J Scheuer
Jul 1, 1993·Journal of Hepatology·F B Bianchi
Jul 1, 1993·Journal of Hepatology·N AbuafJ C Homberg

❮ Previous
Next ❯

Citations

Jan 6, 2011·Clinical Reviews in Allergy & Immunology·Diego Vergani, Giorgina Mieli-Vergani
Feb 28, 2004·Journal of Autoimmunity·Kathie BélandFernando Alvarez
Oct 22, 2003·Journal of Hepatology·Georgios N DalekosMichael P Manns
Jan 6, 2000·Journal of Hepatology·M Ruiz-MorenoA Millàn
Jan 6, 2000·Journal of Hepatology·F Bortolotti
Jul 29, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D ZauliF B Bianchi
Jul 30, 2002·European Journal of Internal Medicine·G N. DalekosN Gatselis
Jun 14, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Luigi MuratoriDiego Vergani
Oct 13, 2000·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·D P BogdanosD Vergani
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maureen M Jonas
Oct 30, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paolo MuratoriMarco Lenzi
Feb 16, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paolo MuratoriFrancesco B Bianchi
Oct 19, 2001·Journal of Clinical Gastroenterology·Y C PengG H Chen
Jan 10, 2002·European Journal of Gastroenterology & Hepatology·Georgios N DalekosMichael P Manns
Feb 27, 2013·Journal of Pediatric Gastroenterology and Nutrition·Jean P MollestonUNKNOWN PEDS-C Clinical Research Network
Sep 18, 2001·Gut·Z Ben-Ari, A J Czaja
May 31, 2012·Clinical & Developmental Immunology·Giuseppe IndolfiMassimo Resti
Nov 8, 2013·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Mohammed E HamedNermin Raafat
Jul 2, 1998·Clinical and Experimental Immunology·G V GregorioD Vergani
Mar 4, 2014·European Journal of Pediatrics·Silvia GarazzinoPier-Angelo Tovo
Oct 5, 2002·Clinics in Liver Disease·Francesco B BianchiLuigi Muratori
Apr 9, 2001·Clinics in Liver Disease·M M Jonas
Sep 6, 2015·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver
May 4, 2001·Journal of Autoimmunity·P Obermayer-Straub, M P Manns
Sep 22, 2009·Journal of Autoimmunity·Maria Serena LonghiDiego Vergani
Jan 11, 2005·World Journal of Gastroenterology : WJG·Eva ZusinaiteRiina Salupere
May 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael R CharltonStephen A Harrison
Oct 13, 2006·Journal of Pediatric Gastroenterology and Nutrition·Kathleen B SchwarzJean Michel Gries
Jul 23, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gabriel MarceauFernando Alvarez
Feb 7, 2018·Hepatology Communications·James E Squires, William F Balistreri
Aug 23, 2020·Journal of Pediatric Gastroenterology and Nutrition·Daniel H LeungShikha S Sundaram
Apr 11, 2018·Frontiers in Immunology·Marcial SebodeChristoph Schramm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Autoimmune Hepatitis

Autoimmune hepatitis formerly called lupoid hepatitis, is a chronic, autoimmune disease of the liver that occurs when the body's immune system attacks liver cells causing the liver to be inflamed. Discover the latest research on autoimmune hepatitis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.