Non-Overt Coagulopathy in Non-ICU Patients with Mild to Moderate COVID-19 Pneumonia

Journal of Clinical Medicine
Daniela MazzaccaroGiovanni Nano

Abstract

Aim of the study is to assess the occurrence of early stage coagulopathy and disseminated intravascular coagulation (DIC) in patients with mild to moderate respiratory distress secondary to SARS-CoV-2 infection. Data of patients hospitalized from 18 March 2020 to 20 April 2020 were retrospectively reviewed. Two scores for the screening of coagulopathy (SIC and non-overt DIC scores) were calculated. The occurrence of thrombotic complication, death, and worsening respiratory function requiring non-invasive ventilation (NIV) or admission to ICU were recorded, and these outcomes were correlated with the results of each score. Chi-square test, receiver-operating characteristic curve, and logistic regression analysis were used as appropriate. p Values < 0.05 were considered statistically significant. Data of 32 patients were analyzed. Overt-DIC was diagnosed in two patients (6.2%), while 26 (81.2%) met the criteria for non-overt DIC. Non-overt DIC score values ≥4 significantly correlated with the need of NIV/ICU (p = 0.02) and with the occurrence of thrombotic complications (p = 0.04). A score ≥4 was the optimal cut-off value, performing better than SIC score (p = 0.0018). Values ≥4 in patients with thrombotic complications were pred...Continue Reading

References

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Citations

Sep 12, 2020·Journal of Clinical Medicine·Alfonso Savastano Gemelli Against Covid-Post-Acute Care Study Group
Oct 13, 2020·Research and Practice in Thrombosis and Haemostasis·Stephan NoppCihan Ay
Dec 10, 2020·Thrombosis Journal·Kochawan BoonyawatPantep Angchaisuksiri
Feb 2, 2021·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Maria Cristina SavastanoUNKNOWN Gemelli Against COVID-19 Post-Acute Care Study Group
Apr 9, 2020·BMJ : British Medical Journal·Laure WynantsMaarten van Smeden
Feb 8, 2021·International Journal of Hematology·Hirotaka MoriTakayuki Ikezoe
Mar 11, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Nicolas GallasteguiTimothy A Morris
Mar 13, 2021·TH Open : Companion Journal to Thrombosis and Haemostasis·Joseph M SweeneyMorayma Reyes Gil
Sep 15, 2021·The Journal of Cardiovascular Surgery·Daniela MazzaccaroGiovanni Nano

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Methods Mentioned

BETA
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STATA

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