Non-palpable breast carcinomas: correlation of mammographically detected malignant-appearing microcalcifications and epidermal growth factor receptor (EGFR) family expression

Cancer Letters
Filitsa A BadraHaralabos P Kalofonos

Abstract

Malignant-appearing microcalcifications (MAMCs) represent one of the earliest mammographic findings of non-palpable breast carcinomas (NPBCs). In the present study, we have evaluated the expression of all EGFR family members in NPBCs and its possible association with MAMCs. Three hundred and fifty patients with non-palpable suspicious breast lesions detected during screening mammography were studied. EGFR family proteins' expression was found to be present since the preclinical phase of breast carcinomas and was strongly correlated (except HER-3) with MAMCs. The co-expression pattern of EGFR family members combined with other molecular prognostic factors and the mammographic appearance might predict the natural history of NPBCs.

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Citations

Oct 9, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Petros D GrivasHaralabos Kalofonos
Jan 27, 2007·The International Journal of Biochemistry & Cell Biology·Michalis V KaramouzisAthanasios G Papavassiliou
Jul 4, 2009·The Lancet Oncology·Michalis V KaramouzisAthanasios G Papavassiliou
Jul 9, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Satu LuhtalaJorma Isola
May 9, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sjoerd G EliasNola M Hylton
Apr 26, 2021·Clinical Imaging·Zhifang HuangRenhua Lv

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