Non-parametric approach for frequentist multiple imputation in survival analysis with missing covariates.

Statistical Methods in Medical Research
Yoshinori TakeuchiYutaka Matsuyama

Abstract

In clinical and epidemiological studies using survival analysis, some explanatory variables are often missing. When this occurs, multiple imputation (MI) is frequently used in practice. In many cases, simple parametric imputation models are routinely adopted without checking the validity of the model specification. Misspecified imputation models can cause biased parameter estimates. In this study, we describe novel frequentist type MI procedures for survival analysis using proportional and additive hazards models. The procedures are based on non-parametric estimation techniques and do not require the correct specification of parametric imputation models. For continuous missing covariates, we first sample imputation values from a parametric imputation model. Then, we obtain estimates by solving the estimating equation modified by non-parametrically estimated conditional densities. For categorical missing covariates, we directly sample imputation values from a non-parametrically estimated conditional distribution and then obtain estimates by solving the corresponding estimating equation. We evaluate the performance of the proposed procedures using simulation studies: one uses simulated data; another uses data informed by paramete...Continue Reading

References

May 20, 2009·Statistics in Medicine·Ian R White, Patrick Royston
Sep 4, 2012·Clinical Therapeutics·Tsochiang MaGwo-Ping Jong
May 3, 2013·Pharmacoepidemiology and Drug Safety·Wei YangHarold I Feldman
May 25, 2013·BMJ : British Medical Journal·Aleesa A CarterMuhammad M Mamdani
Feb 15, 2014·Statistical Methods in Medical Research·Jonathan W BartlettUNKNOWN Alzheimer's Disease Neuroimaging Initiative*
Jul 22, 2015·Statistics in Medicine·Jinhyouk JungSangwook Kang
Nov 23, 2017·American Journal of Epidemiology·Ofer HarelEnrique F Schisterman
Nov 23, 2017·American Journal of Epidemiology·Neil J PerkinsEnrique F Schisterman
May 3, 2018·Statistical Methods in Medical Research·Chiu-Hsieh Hsu, Mandi Yu
May 31, 2018·Statistics in Medicine·Hiroaki TomitaMasayuki Henmi
Oct 22, 2019·PLoS Medicine·Michael FralickAaron S Kesselheim

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