Non-parametric individual treatment effect estimation for survival data with random forests

Bioinformatics
Sami Tabib, Denis Larocque

Abstract

Personalized medicine often relies on accurate estimation of a treatment effect for specific subjects. This estimation can be based on the subject's baseline covariates but additional complications arise for a time-to-event response subject to censoring. In this paper, the treatment effect is measured as the difference between the mean survival time of a treated subject and the mean survival time of a control subject. We propose a new random forest method for estimating the individual treatment effect with survival data. The random forest is formed by individual trees built with a splitting rule specifically designed to partition the data according to the individual treatment effect. For a new subject, the forest provides a set of similar subjects from the training dataset that can be used to compute an estimation of the individual treatment effect with any adequate method. The merits of the proposed method are investigated with a simulation study where it is compared to numerous competitors, including recent state-of-the-art methods. The results indicate that the proposed method has a very good and stable performance to estimate the individual treatment effects. Two examples of application with a colon cancer data and breast c...Continue Reading

References

Feb 8, 1990·The New England Journal of Medicine·C G MoertelJ H Glick
Oct 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M SchumacherH F Rauschecker
Dec 26, 2003·Statistics in Medicine·Torsten HothornMartin Radespiel-Tröger
May 21, 2011·Bioinformatics·Guy Haskin FernaldRuss B Altman
Jul 22, 2014·Statistics in Medicine·Riccardo De BinAnne-Laure Boulesteix
Mar 5, 2016·Statistics in Medicine·Andrew WeyKyle Rudser
May 27, 2016·The International Journal of Biostatistics·Heidi SeiboldTorsten Hothorn
Jul 6, 2016·Lifetime Data Analysis·Hoora MoradianFrançois Bellavance
Apr 4, 2017·Bioinformatics·Weijia ZhangJiuyong Li
Apr 7, 2017·Statistics in Medicine·Per K AndersenErik T Parner
Aug 25, 2017·Statistical Methods in Medical Research·Hoora MoradianFrançois Bellavance
Feb 2, 2018·Statistics in Medicine·Marius ThomasHeidi Seibold
Feb 23, 2019·Statistical Methods in Medical Research·Marie-Hélène Roy, Denis Larocque

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Citations

Aug 3, 2021·Computational and Mathematical Methods in Medicine·Luana Ibiapina Cordeiro Calíope PinheiroPedro Gabriel Calíope Dantas Pinheiro

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