Non-paraneoplastic autoimmune retinopathy: multimodal testing characteristics of 13 cases

Journal of Ophthalmic Inflammation and Infection
Saira KhannaMihai Mititelu

Abstract

Non-paraneoplastic autoimmune retinopathy (npAIR) is a rare autoimmune disease that primarily affects retinal photoreceptor function and results in profound and often times permanent vision loss. Delay in diagnosis and treatment initiation may contribute to the poor visual prognosis. A retrospective chart review of all patients diagnosed with autoimmune retinopathy at the University of Wisconsin-Madison Eye Clinics between January 2012 and January 2017 was performed. Twenty eyes of 15 patients had evidence of any form of autoimmune retinopathy through a combination of symptoms, ocular findings, visual fields, optical coherence tomography, fundus autofluorescence, full-field and multifocal electroretinography, and serum anti-retinal antibodies. Clinical records were also analyzed for demographic data, systemic comorbidities, visual acuity, treatment employed, and disease progression. We identified 18 eyes from 13 patients who fit the criteria for non-paraneoplastic autoimmune retinopathy. Sixty-nine percent of patients were female with a mean age of symptom onset of 56.9 ± 20.3 years. Sixty-seven percent of eyes had an associated autoimmune condition, most commonly hypothyroidism. Serum testing revealed a preponderance of antibo...Continue Reading

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Citations

Apr 23, 2020·Expert Review of Ophthalmology·Grazyna Adamus
Aug 23, 2020·Indian Journal of Ophthalmology·Parthopratim Dutta MajumderAniruddha Agarwal
Aug 24, 2020·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Samuel A Minaker, Radha P Kohly
Dec 10, 2020·International Journal of Retina and Vitreous·Joseph RaevisMihai Mititelu
Oct 30, 2020·Eye·Shaun Sebastian SimChui Ming Gemmy Cheung
Jul 24, 2021·Scientific Reports·Aulia Rahmi PawestriAdisak Trinavarat
Aug 17, 2021·Journal of Ophthalmic Inflammation and Infection·Caleb C NgEmmett T Cunningham

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Methods Mentioned

BETA
imaging techniques

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