Non-peptide oxytocin agonists

Bioorganic & Medicinal Chemistry Letters
Gary R W PittMichael B Roe

Abstract

A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).

References

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Citations

Nov 12, 2013·Expert Opinion on Drug Discovery·Adam Michael Stewart, Allan V Kalueff
Dec 23, 2011·International Journal of Endocrinology·Nikolaos VrachnisZoe Iliodromiti
Jul 16, 2010·CNS Neuroscience & Therapeutics·Cedric VieroGovindan Dayanithi
Nov 22, 2005·Bioorganic & Medicinal Chemistry Letters·Amedeo A FailliC H Park
Mar 22, 2014·Harvard Review of Psychiatry·David M CochranJean A Frazier
May 28, 2019·Molecular Diversity·Gaurangkumar C BrahmbhattMange Ram Yadav
Dec 5, 2008·Journal of Medicinal Chemistry·Christopher M YeaMichael B Roe
Jan 29, 2010·Journal of Medicinal Chemistry·Marie-Céline FrantzMarcel Hibert
Oct 15, 2011·Journal of the American Chemical Society·Ke-Yin YeShu-Li You
Oct 19, 2017·Journal of Medicinal Chemistry·Enza LacivitaMarcello Leopoldo
Sep 11, 2018·Journal of Medicinal Chemistry·Marie-Céline FrantzMarcel Hibert
Nov 15, 2005·Journal of Combinatorial Chemistry·Roland E Dolle

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