Non-Pharmacological Interventional Perspectives in AMD

Klinische Monatsblätter für Augenheilkunde
G Thumann, Peter Walter

Abstract

Transplantation and translocation surgery for the treatment of AMD has been evaluated for over 25 years. More recently injections of inhibitors of vascularisation have been used with some success. Inhibitors of neovascularisation result in the recovery of vision in about 30% of patients; however, we do not understand what criteria can be used to select patients who will respond to or will not respond to treatment with antivascularisation treatment. We have to assume that successful antivascularisation treatment will require first that the retinal pigment epithelial cells be present and functional and second that the photoreceptor cells should not be degenerated. We then hypothesise that if either of these two parameters are not present, antivascular treatment will not result in vision recovery and we must then consider surgical intervention. Surgical intervention for macular degeneration encompasses procedures from simple membrane extraction to macular rotation to cell transplantation or a combination of these procedures, however these procedures must take into account that vision recovery cannot be achieved without reconstruction of the retina-choroid complex. Since in AMD degeneration of the retinal pigment epithelial cells a...Continue Reading

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