Non-pharmacological management for patients with frontotemporal dementia: a systematic review

Journal of Alzheimer's Disease : JAD
Shunichiro ShinagawaBruce L Miller

Abstract

Frontotemporal dementia (FTD) is a neurodegenerative disorder characterized by changes in behavior and language caused by focal degeneration of the frontal and anterior temporal lobes. The behavioral symptoms are distressing to patients and their caregivers. Non-pharmacological management is important as no disease-specific pharmacological treatment for FTD is currently available. The primary objective is to review the literature on non-pharmacological management for FTD and to propose directions for future research, with reference to findings. A search was performed using PubMed, MEDLINE, and EMBASE. Search terms included "frontotemporal dementia", and words related to non-pharmacological management, and it identified a total of 858 articles. Results revealed that very few randomized controlled trials exist on non-pharmacological management interventions for FTD. These interventions have been proposed by literature based on clinical experience. A small number of studies have supported behavioral management techniques that exploit disease-specific behaviors and preserved functions in patients with FTD, along with the management of caregivers' distress. These limitations warrant well-designed large-scale research to examine effe...Continue Reading

Citations

Apr 16, 2019·International Psychogeriatrics·Tina KarnatzJochen René Thyrian
Mar 7, 2020·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Calvin TrieuAnnemieke Dols
Jan 12, 2016·Current Neurology and Neuroscience Reports·Cynthia BartonBruce Miller
Jan 14, 2020·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Kenji TagaiMasahiro Shigeta
Aug 10, 2016·Journal of Geriatric Psychiatry and Neurology·Tor Atle RosnessZeina Chemali
Apr 12, 2021·CNS Drugs·Rita KhouryGeorge T Grossberg
Nov 14, 2018·Dementia and Geriatric Cognitive Disorders·Courtney LewisAdam P Vogel

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