PMID: 8972927Nov 1, 1996Paper

Non-prescribed drug use during methadone treatment by clinic- and community-based patients

Addiction
K WolffD Raistrick

Abstract

We investigated the efficacy of methadone maintenance treatment in clinic-based (n = 10) and community-based (n = 10) patients by studying the relationships between dose, plasma concentrations of methadone and non-prescribed drug-use using logistic regression. We found that clinic-based patients had significantly reduced odds of having a urine sample test positive for illicit drugs when compared to community-based patients (OR = 0.20; 95% confidence interval 0.10-0.38: p < 0.001). There was no relationship between either methadone dose or plasma methadone concentration and testing positive for non-prescribed drugs (including cocaine, cannabis, amphetamine, ecstasy, benzodiazepines). We looked specifically at the misuse of opiate drugs. Location was again important and clinic-based patients had significantly reduced odds of having a urine sample test positive for opiate drugs (OR = 0.36, 95% confidence interval 0.18-0.71: p approximately 0.004). Opiate drug use in our patients was also significantly related to plasma methadone concentration, increasing noticeably when the drug concentration < 0.48 nmol/L (p approximately 0.04). We found no relationship between methadone dose and odds of having a positive urine drug test in eithe...Continue Reading

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Citations

Feb 26, 1998·Drug and Alcohol Dependence·D BestJ Strang
Dec 5, 1998·Drug and Alcohol Dependence·D A WassermanS M Hall
Mar 19, 2002·Therapeutic Drug Monitoring·Edward J Cone, Kenzie L Preston

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