Abstract
We investigated the efficacy of methadone maintenance treatment in clinic-based (n = 10) and community-based (n = 10) patients by studying the relationships between dose, plasma concentrations of methadone and non-prescribed drug-use using logistic regression. We found that clinic-based patients had significantly reduced odds of having a urine sample test positive for illicit drugs when compared to community-based patients (OR = 0.20; 95% confidence interval 0.10-0.38: p < 0.001). There was no relationship between either methadone dose or plasma methadone concentration and testing positive for non-prescribed drugs (including cocaine, cannabis, amphetamine, ecstasy, benzodiazepines). We looked specifically at the misuse of opiate drugs. Location was again important and clinic-based patients had significantly reduced odds of having a urine sample test positive for opiate drugs (OR = 0.36, 95% confidence interval 0.18-0.71: p approximately 0.004). Opiate drug use in our patients was also significantly related to plasma methadone concentration, increasing noticeably when the drug concentration < 0.48 nmol/L (p approximately 0.04). We found no relationship between methadone dose and odds of having a positive urine drug test in eithe...Continue Reading
References
Jan 1, 1978·Annals of the New York Academy of Sciences·H D Kleber, M S Gold
Jan 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·G Edwards
Jan 1, 1992·Journal of Substance Abuse Treatment·H J Shaffer, T A LaSalvia
Apr 1, 1991·Journal of Psychoactive Drugs·A Goldstein
Apr 1, 1991·Journal of Psychoactive Drugs·C R Schuster
Apr 1, 1991·Journal of Psychoactive Drugs·J MartinJ E Zweben
Apr 1, 1990·Drug and Alcohol Dependence·D Ladewig, A Scholer
Dec 1, 1990·British Journal of Addiction·J BellR Batey
Sep 1, 1990·Annals of Clinical Biochemistry·K WolffA W Hay
Sep 22, 1989·JAMA : the Journal of the American Medical Association·V P Dole
May 1, 1987·British Journal of Addiction·K M PereraF A Jenner
Sep 1, 1985·The International Journal of the Addictions·M Allison, R L Hubbard
Sep 1, 1988·Journal of Health and Social Behavior·J C BallS R Friedman
Oct 1, 1987·The American Journal of Psychiatry·F S Tennant
Oct 1, 1966·Archives of Internal Medicine·V P DoleM J Kreek
Mar 21, 1970·Lancet·M MitchesonL Hitchens
May 30, 1970·Lancet·G V Stimson, A C Ogborne
Mar 10, 1984·British Medical Journal·P H Connell, M Mitcheson
Jan 1, 1982·The American Journal of Drug and Alcohol Abuse·B S BrownA S Iglehart
Feb 1, 1980·Archives of General Psychiatry·W LingW E Carter
Jul 1, 1980·The International Journal of the Addictions·R J Craig
Oct 15, 1994·BMJ : British Medical Journal·M FarrellJ Strang
Jul 1, 1993·Annals of Internal Medicine·E C StrainG E Bigelow
Citations
Feb 26, 1998·Drug and Alcohol Dependence·D BestJ Strang
Dec 5, 1998·Drug and Alcohol Dependence·D A WassermanS M Hall
Dec 5, 1998·Drug and Alcohol Dependence·M TorrensR de la Torre
Jan 21, 2004·The Australian and New Zealand Journal of Psychiatry·Tal WeizmanAvraham Bleich
Mar 19, 2002·Therapeutic Drug Monitoring·Edward J Cone, Kenzie L Preston