PMID: 518307Jan 1, 1979Paper

Non-productive paramyxovirus infection: Nariva virus infection in hamsters

Archives of Virology
R P Roos, R Wollmann

Abstract

The pathogenesis of infection with Nariva virus (NV)--recently classified as a paramyxovirus--was studied in the hamster, an animal closely related to the natural host. Intracranial inoculation of suckling hamsters produces an acute necrotizing encephalitis with large amounts of infectious virus and virus antigen in the brain. In contrast, weanling hamsters have only small amounts of infectious virus and only early in the disease, when they are well; later, when clinically ill, they have a non-productive infection with continuing evidence of viral antigen, but no detectable infectious virus. Weanlings die later than sucklings with less cerebral parenchymal necrosis. The integrity of the immune system affects the expression of NV since brain tissue from anti-lymphocyte serum (ALS) treated infected weanling hamsters have more infectious virus, and for longer periods, than brain tissue from untreated infected weanling hamsters. Changing susceptibility of the host's neural cells may also be involved in determining the course of the illness and expression of the virus since: 1) ALS treatment does not influence the clinical course of the disease or pathology, 2) ALS treated weanlings still have much lower levels of infectious virus t...Continue Reading

References

May 1, 1976·Infection and Immunity·K ShimokataI Nagata
May 1, 1976·Journal of Neuropathology and Experimental Neurology·J S WolinskyL B Rorke
Jun 1, 1978·The Journal of Infectious Diseases·R P RoosR T Johnson
Dec 1, 1976·The Journal of Infectious Diseases·S Krakowka, A Koestner
May 1, 1971·The Journal of General Virology·R Walder
Mar 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·N KarabatsosP Ardoin

❮ Previous
Next ❯

Citations

Jan 1, 1989·Journal of Comparative Pathology·W BaumgärtnerJ R Gorham

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.