Non-protein biologic therapeutics

Current Opinion in Biotechnology
Susan T Sharfstein

Abstract

While the therapeutic biologics are dominated by therapeutic proteins, particularly monoclonal antibodies, a wide range of non-protein therapeutic biologics are rapidly gaining ground both in clinical studies and approved products. Many of these first-in-class therapies provide novel treatment modalities and address previously untreatable conditions or undruggable targets. In particular, novel treatments for rare genetic disorders and qualitatively different oncology therapeutics have been approved in the last two years. This review discusses recent advances in peptide, nucleic acid, carbohydrate, vaccine, and cell-based therapies as well as the manufacturing and commercialization challenges associated with these novel therapeutics.

Citations

Mar 10, 2019·Protein Science : a Publication of the Protein Society·Jean A BoutinHubert Vaudry
Feb 15, 2019·Current Drug Delivery·Jieru YangMariusz Skwarczynskia
Nov 5, 2020·Organic & Biomolecular Chemistry·Eike B Bauer
Jan 14, 2020·Molecular Therapy. Nucleic Acids·Yuhua WengXing-Jie Liang
Mar 12, 2021·Advanced Drug Delivery Reviews·Yajie ZhangRobert O Williams
Aug 22, 2018·Biomacromolecules·Elena AmbrosioStefano Salmaso

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