Non-psychotropic medication and risk of suicide or attempted suicide: a systematic review

BMJ Open
Hayley C GortonDarren M Ashcroft

Abstract

To establish which non-psychotropic medications have been assessed in relation to risk of suicide or attempted suicide in observational studies, document reported associations and consider study strengths and limitations. Systematic review. Four databases (Embase, Medline, PsycINFO and International Pharmaceutical Abstracts) were searched from 1990 to June 2014, and reference lists of included articles were hand-searched. Case-control, cohort and case only studies which reported suicide or attempted suicide in association with any non-psychotropic medication were included. The outcomes eligible for inclusion were suicide and attempted suicide, as defined by the authors of the included study. Of 11,792 retrieved articles, 19 were eligible for inclusion. Five studies considered cardiovascular medication and antiepileptics; two considered leukotriene receptor antagonists, isotretinoin and corticosteroids; one assessed antibiotics and another assessed varenicline. An additional study compared multiple medications prescribed to suicide cases versus controls. There was marked heterogeneity in study design, outcome and exposure classification, and control for confounding factors; particularly comorbid mental and physical illness. No i...Continue Reading

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Citations

Oct 26, 2018·Journal of Neurology·Hayley C GortonDarren M Ashcroft
Jun 9, 2020·Experimental and Therapeutic Medicine·Ana Maria Alexandra StanescuCamelia Cristina Diaconu
Sep 1, 2017·Frontiers in Psychiatry·Domenico De BerardisMassimo Di Giannantonio
Jun 14, 2018·JAMA : the Journal of the American Medical Association·Dima Mazen QatoMark Olfson
Apr 6, 2019·BMC Health Services Research·Anne ReneflotJorid Kalseth

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