Non-Radiographic Axial Spondyloarthritis (nr-axSpA): Advances in Classification, Imaging and Therapy

Rheumatology and Therapy
Philip C RobinsonStefan Siebert

Abstract

Non-radiographic axial spondyloarthritis (nr-axSpA) is a recently described form of axial inflammatory arthritis that has not caused substantial erosive damage to the sacroiliac joints. Nr-axSpA is associated with significant impairment in quality of life and, in a proportion of patients, it can evolve into ankylosing spondylitis (AS, also termed radiographic axSpA). The identification in the clinic of nr-axSpA has been made possible by advances in magnetic resonance imaging (MRI). Classification criteria for nr-axSpA have been proposed but there remains discussion in the international community regarding this. Studies are ongoing to further define the classification and diagnosis of nr-axSpA. There is much further research required regarding the optimal use of MRI in nr-axSpA, including distinguishing sacroiliac MRI changes in the normal population and the definition of a positive MRI in spinal disease. Non-steroidal anti-inflammatory drugs and physiotherapy are the core first-line therapy for nr-axSpA. Tumour necrosis factor inhibitors also play a very important role in treatment of patients with active nr-axSpA who do not respond to first-line therapy. Agents directed at interleukin-17, interleukin-23 and Janus kinase inhibi...Continue Reading

References

Aug 19, 2000·The American Journal of Gastroenterology·G F BonnerM Bayona
Mar 31, 2004·Annals of the Rheumatic Diseases·M C W CreemersP L C M van Riel
Jun 17, 2006·Best Practice & Research. Clinical Rheumatology·Nurullah AkkocMuhammad Asim Khan
Jun 6, 2009·Current Opinion in Rheumatology·Walter P Maksymowych
Jan 13, 2011·BMJ : British Medical Journal·Sven TrellePeter Jüni
Nov 15, 2011·Arthritis and Rheumatism·Yao GongQing-Yu Zeng
May 16, 2012·Annals of the Rheumatic Diseases·Kay-Geert A HermannUNKNOWN Assessment in SpondyloArthritis international Society (ASAS)
Oct 27, 2012·Annals of the Rheumatic Diseases·Philip Cameron RobinsonMatthew A Brown
Aug 21, 2013·Annals of the Rheumatic Diseases·Sofia RamiroRobert Landewé
Aug 29, 2014·Arthritis Research & Therapy·Philip C Robinson, Matthew A Brown
Nov 25, 2014·Arthritis & Rheumatology·Mary-Ellen CostelloMatthew A Brown
Jun 7, 2015·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingClément Prati
Aug 20, 2015·Current Rheumatology Reports·Sjef van der LindenMuhammad A Khan
Sep 13, 2015·Best Practice & Research. Clinical Rheumatology·Mary-Ellen CostelloMatthew A Brown
Dec 25, 2015·The New England Journal of Medicine·Dominique BaetenUNKNOWN MEASURE 2 Study Group
Jan 16, 2016·Annals of the Rheumatic Diseases·Robert G W LambertRobert Landewé
Feb 3, 2016·The Journal of Rheumatology·Féline P B KroonDésirée van der Heijde
Apr 21, 2016·Clinical Rheumatology·Nurullah Akkoc, Muhammad A Khan

❮ Previous
Next ❯

Citations

May 27, 2020·Current Opinion in Rheumatology·Christopher Martey, Raj Sengupta
Oct 1, 2020·Clinical Rheumatology·Diego Benavent, Victoria Navarro-Compán
Oct 15, 2020·Rheumatology·George E Fragoulis, Stefan Siebert
Oct 15, 2020·Rheumatology·Rosemarie BarnettRaj Sengupta
Dec 29, 2020·Nature Reviews. Rheumatology·Philip C RobinsonWilliam J Taylor
Apr 29, 2021·Current Rheumatology Reports·David F L LiewPhilip C Robinson
Aug 31, 2021·Journal of Clinical Orthopaedics and Trauma·Amit ShahWinston J Rennie

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Clinical Trials Mentioned

NCT02696031
NCT02757352
NCT03552276
NCT03502616
NCT03178487

Software Mentioned

SPARTAN

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Therapeutic Advances in Musculoskeletal Disease
Denis Poddubnyy
Lancet
Joachim Sieper, Denis Poddubnyy
F1000prime Reports
David I Daikh, Patty P Chen
© 2022 Meta ULC. All rights reserved