PMID: 108228Apr 15, 1979

Non-random duplication of chromosome 15 in murine T-cell leukemias induced in mice heterozygous for translocation T(14:15)6

International Journal of Cancer. Journal International Du Cancer
F WienerG Klein

Abstract

Trisomy of chromosome 15 is a highly regular feature of murine T-cell leukemogenesis. We have studied the chromosomal constitution of 7,12-dimethylbenza(a)anthracene (DMBA)-induced T-cell leukemias in C57BL X CBAT6T6 F1 mice. The CBAT6T6-derived chromosome T(14:15)6 was regularly duplicated whereas the C57BL-derived normal chromosome 15 was only present in one copy. It was concluded that the gene(s) that tend to duplicate in parallel with the neoplastic transformation of the prothymocyte to an overt leukemic cell have a greater chance of duplicating and/or may have a stronger promoting effect on leukemogenesis if stronger promoting effect on leukemogenesis if located on the CBA-derived, structurally rearranged T(14:15)6 than the corresponding genes located on the C57BL-derived normal chromosome 15.

References

Jan 1, 1975·Annual Review of Genetics·O J Miller, D A Miller
Oct 15, 1978·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein
May 1, 1978·Cellular Immunology·N Haran-GheraG Goldstein
Apr 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·R DofukuL J Old
Jan 12, 1972·Nature: New Biology·H C Wang, S Fedoroff
Nov 21, 1973·Nature: New Biology·N Haran-Ghera

Citations

Nov 1, 1980·Somatic Cell Genetics·R T TaggartU Francke
Jun 1, 1983·Cancer Genetics and Cytogenetics·S S BoggsD F Saxe
Apr 1, 1984·Cancer Genetics and Cytogenetics·M CianfrigliaM Nabholz
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M HaasO W Jones
Oct 15, 1982·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·W WeberM Jeannet
Nov 15, 1980·International Journal of Cancer. Journal International Du Cancer·F WienerG Klein
May 15, 1988·International Journal of Cancer. Journal International Du Cancer·S SilvaG Klein
Dec 1, 1981·International Journal of Cancer. Journal International Du Cancer·E W HerbstC Tietgen
Jan 1, 1984·Journal of Cellular Physiology. Supplement·N C CacciaG Klein
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·Z WirschubskyG Klein

Related Concepts

Genetic Carriers
Leukemia, Experimental
Mice, Inbred CBA
Mice, Inbred C57BL
Neoplasm Transplantation
T-Lymphocyte
Chromosomal Translocation
Transplantation, Homologous
Partial Trisomy
9,10-Dimethyl-1,2-benzanthracene

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