Non-random migration of CD4 and CD8 T cells: changes in the CD4: CD8 ratio and interleukin 2 responsiveness of efferent lymph cells following in vivo antigen challenge

European Journal of Immunology
R BujdosoI McConnell

Abstract

In this investigation we have examined some of the cellular and molecular changes in efferent lymph that drains from an antigen-stimulated peripheral lymph node. Resting efferent lymph is characterized by a higher percentage of CD4+ cells and consequently, a higher CD4/CD8 ratio than peripheral blood. Following antigen stimulation of a cannulated peripheral lymph node in antigen-primed sheep, the percentage of CD4+ cells in efferent lymph increases above the resting level during days 1, 2 and 3 post antigen stimulation. This is followed on days, 3, 4, and 5 after antigen stimulation by an increase in the percentage of CD8+ cells above the resting level which occurs as the percentage of CD4+ cells returns to the resting level. These changes cause the CD4/CD8 ratio to first increase above the resting value during the CD4 phase and then decrease below the resting value during the CD8 phase. During the CD4 phase a lymphokine activity is present in cell-free lymph fluid. Lymph fluid collected at this time supports the proliferation of activated T cells. Supernatants generated from efferent cells collected at a similar time and cultured in vivo for 24 h without any further stimulation are capable of releasing this material. During th...Continue Reading

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Citations

Jan 1, 1991·Developmental and Comparative Immunology·B H ThorpW G Kimpton
Nov 1, 1993·Veterinary Immunology and Immunopathology·R BujdosoI McConnell
Nov 1, 1993·Veterinary Immunology and Immunopathology·B T LundR Bujdoso
Apr 1, 1994·Veterinary Immunology and Immunopathology·V M BowlesM R Brandon
Nov 1, 2001·Developmental and Comparative Immunology·Charles A WestSteven J Mentzer
Nov 1, 1996·Veterinary Immunology and Immunopathology·A D NashV M Bowles
May 8, 1999·Immunology·D M HaigH R Miller
Aug 14, 1999·Immunology·A TanegashimaT Fukunaga
Aug 8, 2014·PLoS Computational Biology·Johannes TextorJoost B Beltman
Jan 10, 2017·Frontiers in Immunology·Morgan C HunterCornelia Halin
Oct 12, 2004·Burns : Journal of the International Society for Burn Injuries·T SjöbergL Salemark
Jan 17, 2015·Expert Review of Vaccines·Thilini An MahakapugeJean-Pierre Y Scheerlinck
Sep 1, 1992·European Journal of Immunology·C R MackayL Dudler
May 1, 2021·International Journal of Molecular Sciences·Louise A Johnson

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