PMID: 7547782Aug 1, 1995Paper

Non-retinovascular leakage in diabetic maculopathy

The British Journal of Ophthalmology
D WeinbergerY Yassur

Abstract

Diabetic macular oedema is the leading cause of vision deterioration in diabetic retinopathy. Extracellular fluid within the retina, which distorts the retinal architecture, was assumed to be strictly of retinal vasculature origin. However, there is some experimental evidence supporting clinical observations suggesting a possible role of the retinal pigment epithelium (RPE). An unusual form of diabetic maculopathy is presented in which the RPE and the subretinal space play the main role. Fluorescein angiograms of 1850 non-proliferative diabetic retinopathy (NPDR) patients were examined. Nineteen eyes (14 patients, 1% of NPDR patients) met the criteria-mainly having minimal diabetic retinopathy with only a few microaneurysms and no clinically significant macular oedema (CSMO). Early phase angiograms were compared with late phase angiograms. It was found that in all 19 eyes the area of diffuse RPE late phase leakage was spread around the macular area. No cystic changes or cystoid macular oedema were present in any of the eyes and the visual acuity was 6/10 or better in all the eyes. Possible changes occur in the RPE that may be responsible for the late leakage in NPDR patients-namely, diabetic retinal pigment epitheliopathy. Thes...Continue Reading

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Citations

Oct 26, 2007·Documenta Ophthalmologica. Advances in Ophthalmology·Marilyn E SchneckAnthony J Adams
Jun 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Hui-Zhuo XuYun-Zheng Le
Sep 4, 1998·American Journal of Ophthalmology·D WeinbergerY Yassur
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Aug 25, 2015·Progress in Retinal and Eye Research·Alan W StittNoemi Lois
Jan 25, 2007·Acta Ophthalmologica Scandinavica·Aljoscha S NeubauerMichael W Ulbig
Apr 8, 2016·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Eui Chun KangSuk Ho Byeon
May 20, 2016·PloS One·Phillip S CoburnMichelle C Callegan
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Oct 31, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sonja G KarstUrsula Schmidt-Erfurth
Oct 29, 2020·Journal of Diabetes Research·Ioana Damian, Simona Delia Nicoara
Jan 26, 2021·Journal of Diabetes Research·Corina-Iuliana SuciuSimona-Delia Nicoara
Mar 23, 2021·Investigative Ophthalmology & Visual Science·Shuxin FanXialin Liu
Nov 15, 2020·Progress in Retinal and Eye Research·Deoye Tonade, Timothy S Kern
May 8, 2021·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zeynep Banu DoğanlarEsra Turgut

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