Non-reversible airway obstruction in never smokers: results from the Austrian BOLD study

Respiratory Medicine
B LamprechtM Studnicka

Abstract

The presence of non-reversible airway obstruction (AO) in never smokers has only received limited attention until now. We analyzed data from the Austrian Burden of Obstructive Lung Disease (BOLD) study. We defined non-reversible AO as post-bronchodilator FEV(1)/FVC <0.7 which corresponds to COPD I and higher (COPD I+) according to current GOLD guidelines. Significant AO was defined as FEV(1)/FVC <0.7 and FEV(1) <80% predicted (GOLD II and higher, GOLD II+). The prevalence and characteristics of non-reversible AO in never smokers were analyzed in relation to the severity of the disease. Never smokers comprised 47.3% of the study population. Non-reversible AO was seen in 18.2% of never smokers, and 5.5% of never smokers fulfilled criteria for significant non-reversible AO (GOLD stage II+). Therefore, the resulting population prevalence of significant non-reversible AO (GOLD stage II+) was 2.6%. Never smokers with non-reversible AO were predominantly female and slightly older. The airway obstruction was found to be less severe as compared with ever smokers. Despite this, 20% of never smokers with significant non-reversible AO (GOLD stage II+) reported respiratory symptoms and 50% reported impairment of quality of life. This burden...Continue Reading

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Citations

Oct 5, 2010·Chest·Bernd LamprechtUNKNOWN BOLD Collaborative Research Group
Jun 23, 2015·Journal of Internal Medicine·G BergströmA Rosengren
Jun 19, 2015·American Journal of Respiratory Cell and Molecular Biology·Chorong KimChoon-Sik Park
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Nov 3, 2016·The Clinical Respiratory Journal·Wonjun JiYoonki Hong
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Feb 8, 2018·Proteomics. Clinical Applications·Angela BarallaCiriaco Carru
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Apr 10, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Chantal Raherison-SemjenDave Singh

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