Non-ribosomal peptides produced by Brazilian cyanobacterial isolates with antimicrobial activity

Microbiological Research
Maria Estela Silva-StenicoMarli Fátima Fiore

Abstract

Cyanobacterial strains isolated from terrestrial and freshwater habitats in Brazil were evaluated for their antimicrobial and siderophore activities. Metabolites of fifty isolates were extracted from the supernatant culture media and cells using ethyl acetate and methanol, respectively. The extracts of 24 isolates showed antimicrobial activity against several pathogenic bacteria and one yeast. These active extracts were characterized by Q-TOF/MS. The cyanobacterial strains Cylindrospermopsis raciborskii 339-T3, Synechococcus elongatus PCC7942, Microcystis aeruginosa NPCD-1, M. panniformis SCP702 and Fischerella sp. CENA19 provided the most active extracts. The 50 cyanobacterial strains were also screened for the presence of non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) genes and microcystin production. Putative fragment genes coding for NRPS adenylation domains and PKS keto-synthase domains were successfully PCR amplified from 92% and 80% of cyanobacterial strains, respectively. The potential therapeutical compounds siderophores were detected in five cyanobacterial isolates. Microcystin production was detected by ELISA test in 26% of the isolates. Further a protease inhibitor substance was detected by LC...Continue Reading

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Citations

Jan 25, 2013·Marine Drugs·Hanna Mazur-MarzecJussi Meriluoto
Jan 28, 2014·Systematic and Applied Microbiology·Caroline Souza Pamplona SilvaMarli Fátima Fiore
Dec 4, 2015·International Journal of Molecular Sciences·Rafael R C CuadratAlberto M R Dávila
Oct 31, 2014·Letters in Applied Microbiology·O C S SantosM S Laport
Jun 26, 2012·The Science of the Total Environment·Haywood Dail LaughinghouseSolange Bosio Tedesco
Jul 5, 2012·FEMS Microbiology Ecology·Ronaldo Leal CarneiroErnani Pinto
Sep 11, 2017·Biomolecular Concepts·Luis O De Serrano
Jun 28, 2020·Environmental Science and Pollution Research International·Medina O KadiriMathias Ahii Chia
May 15, 2019·Marine Drugs·Erland Årstøl, Martin F Hohmann-Marriott
Mar 9, 2018·Frontiers in Microbiology·Rafael R C CuadratHans-Peter Grossart
Dec 6, 2019·Frontiers in Microbiology·Megan M MullisBrandi Kiel Reese
Dec 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Verónica RojasFanny Guzmán
Sep 28, 2021·Journal of Chemical Ecology·Mauro Cesar Palmeira VilarSandra Maria Feliciano de Oliveira E Azevedo
Nov 21, 2021·Environmental Science and Pollution Research International·Alane Silva de Aquino SantosAriadne do Nascimento Moura

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