Non-Robertsonian translocations involving chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the literature

Medicine
Hongguo ZhangRuizhi Liu

Abstract

For genetic counseling of male carriers of chromosomal translocations, the specific chromosomes and breakpoints involved in the translocation are relevant to know. The structural chromosomal abnormalities may lead to abnormal sperm counts, infertility, and miscarriage. These are related to the specific chromosomes and breakpoints involved in the translocation. To date, over 200 cases of non-Robertsonian translocation in male carriers have been described that involve chromosomes 13, 14, or 15.This study reports of 28 male carriers from our clinic with balanced reciprocal translocations of chromosome 13, 14, or 15, and a literature review of 201 cases. The 28 male carriers from our clinic were diagnosed by cytogenetic analyses: 19 subjects suffered from pregestational infertility and 9 from gestational infertility. The most common translocations were t(7;13), t(10;14), and t(3;15), observed respectively in 13 (46%), 8 (29%), and 8 (29%) of our subjects. The literature cases (n = 201) involved chromosome 13 (n = 83, 41%), chromosome 14 (n = 56, 28%) or 15 (n = 62, 31%) in which 75 breakpoints were identified, the most common breakpoint, 13q22, was observed in 12 subjects (6%), followed by 14q32 (n = 11), 15q15 (n = 9), and 15q22 (...Continue Reading

References

Nov 15, 2011·Human Reproduction·E C DulJ A Land
Nov 29, 2011·Asian Journal of Andrology·Gary L Harton, Helen G Tempest
May 15, 2012·Journal of Assisted Reproduction and Genetics·Dingyang LiRuizhi Liu
Mar 25, 2014·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Hanwei JiangQinghua Shi
Apr 29, 2014·Annales d'endocrinologie·Katrien StouffsWilly Lissens
Jun 5, 2015·Systems Biology in Reproductive Medicine·Vladimir SobotkaJiri Rubes
Dec 23, 2015·Folia Histochemica Et Cytobiologica·Ewa PastuszekKrzysztof Lukaszuk

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Citations

Oct 27, 2020·Frontiers in Endocrinology·Robert John Aitken, Mark A Baker
Dec 19, 2020·Open Medicine·Ranwei LiShuqiang Feng
Aug 7, 2021·Horticulture Research·Shi-Ping ChengJian-Feng Mao

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Methods Mentioned

BETA
chromosomal aberrations

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