Non-selective impairment of Wisconsin Card Sorting Test performance in patients with schizophrenia

Schizophrenia Research
M DieciG Invernizzi

Abstract

Sixty-two schizophrenic patients and 26 healthy volunteers were administered the Wisconsin Card Sorting Test (WCST) a task putatively specific for frontal functions and the Wechsler Adult Intelligence Scale (WAIS). The purpose of this study was to evaluate the presence of specific frontal lobe deficits in the course of schizophrenia and the capacity of these tasks to discriminate between patients and controls. Schizophrenic patients showed a poorer performance than control subjects in both tests. No evidence emerged to support a higher discriminant power for the WCST in identifying schizophrenic subjects from healthy controls compared with the WAIS. Our data suggest that the deficit in WCST performance is not selective, but rather part of a more generalized neuropsychological impairment in schizophrenic patients.

References

Jan 1, 1978·Journal of Psychiatric Research·L J Chapman, J P Chapman
Nov 1, 1992·The International Journal of Neuroscience·O GambiniS Scarone
Mar 1, 1992·Schizophrenia Research·P FrankeT Klingler
Nov 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·S L Morrison-StewartH Merskey
Nov 1, 1991·Journal of Abnormal Psychology·A T SummerfeltM E Strauss
Nov 1, 1991·Journal of Clinical and Experimental Neuropsychology·S W AndersonD Tranel
Nov 1, 1990·Psychological Medicine·P J McKennaA D Baddeley
May 1, 1990·Psychological Medicine·H E NelsonT R Barnes
Jul 1, 1990·The British Journal of Psychiatry : the Journal of Mental Science·R Morice
Jan 1, 1988·Schizophrenia Bulletin·T E Goldberg, D R Weinberger
Aug 1, 1988·Journal of Clinical and Experimental Neuropsychology·B P HermannE T Richey
Sep 1, 1988·The International Journal of Neuroscience·T E GoldbergK F Berman
Jun 1, 1986·Journal of Clinical and Experimental Neuropsychology·E T Heck, J B Bryer
Nov 1, 1986·The International Journal of Neuroscience·D CrockettJ Kozak
Jun 1, 1974·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·E A Drewe
Jan 1, 1984·Schizophrenia Bulletin·E AylwardB Bettes
Aug 1, 1984·Journal of Abnormal Psychology·C D Frith
Jan 1, 1983·Neuropsychologia·D T StussD Ferrill
Apr 1, 1982·Journal of Clinical Psychology·M G Pendleton, R K Heaton
May 1, 1995·Psychological Medicine·R ElliottB J Sahakian
Feb 1, 1994·Schizophrenia Research·T E Goldberg, D R Weinberger
Sep 1, 1974·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·H P Malmo

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Citations

Jul 3, 2003·Schizophrenia Research·Ralf PukropJoachim Klosterkötter
Sep 24, 2010·Psychological Medicine·J W CarterS A Mednick
Sep 10, 1999·Acta Psychiatrica Scandinavica·B R Rund, N E Borg
Feb 19, 2009·Schizophrenia Research·Allyssa J AllenGodfrey D Pearlson
Mar 17, 2007·Schizophrenia Research·I J OsujiC M Cullum
Jun 26, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·D TempestaD De Berardis
Nov 14, 2016·Psychiatry Research·Mehala SubramaniapillaiGuy Faulkner
Jan 25, 2002·American Journal of Medical Genetics·Jacobus DondersSteven van Doornik
Apr 15, 2016·Harvard Review of Psychiatry·Paola LandiLiliana Dell'Osso

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