Non-self-discrimination as a driving concept in the identification of an immunodominant HMW-MAA epitopic peptide sequence by autoantibodies from melanoma cancer patients

International Journal of Cancer. Journal International Du Cancer
Reinhard DummerDarja Kanduc

Abstract

We analyzed the sera of patients with melanoma to define the human humoral autoantibody profile towards HMW-MAA. Computational proteome scanning using the non-self-discrimination principle as a guide led to the individuation of the low-similarity HMW-MAA781-789RATVWMLRL peptide fragment as an immunodominant B-cell epitope. Linear B-cell determinant individuation was experimentally validated by dot blot immunoassay and NMR spectroscopy analysis. Regulation of physiologic self-reactivity by the non-self-discrimination principle is discussed.

References

Jun 1, 1990·Immunological Reviews·M Cohn, R E Langman
Jan 1, 1988·Annual Review of Immunology·M Herlyn, H Koprowski
Jan 1, 1994·Annual Review of Immunology·P Matzinger
Mar 1, 1994·Journal of Biomolecular NMR·J SchleucherC Griesinger
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·G PluschkeR A Reisfeld
Jan 7, 1998·Immunological Reviews·A M Silverstein, N R Rose
May 23, 1998·The Journal of Experimental Medicine·E StockertL J Old
Oct 9, 1998·The Journal of Investigative Dermatology·S K HuangD S Hoon
May 14, 1999·Current Opinion in Immunology·C PinillaR A Houghten
Dec 10, 1999·The Journal of Experimental Medicine·W B BowneA N Houghton
Jul 27, 2000·Seminars in Immunology·N A MitchisonB Chain
Jul 27, 2000·Seminars in Immunology·A I Tauber
May 2, 2001·Gynecologic Oncology·J R BosscherD D Taylor
Jul 18, 2001·Journal of the American Chemical Society·S SchwarzingerH J Dyson
Feb 20, 2002·Biologicals : Journal of the International Association of Biological Standardization·M H Van Regenmortel
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Abraham MittelmanDarja Kanduc
Jun 25, 2002·Pediatric Hematology and Oncology·Merlin R HamreRichard K Severson
Jul 2, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K F KölmelC Seebacher
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu WangWei-Feng Chen
Oct 9, 2002·JAMA : the Journal of the American Medical Association·Alan C GellerHoward K Koh

❮ Previous
Next ❯

Citations

Dec 14, 2004·Journal of Translational Medicine·Alberta LuccheseAnimesh A Sinha
Aug 24, 2006·Journal of Translational Medicine·Alberta LuccheseDarja Kanduc
Oct 26, 2006·Journal of Translational Medicine·Giovanni AngeliniDarja Kanduc
Dec 18, 2013·Immunotherapy·Jean Pierre Spinosa, Darja Kanduc
Jul 14, 2010·Journal of Biomedicine & Biotechnology·Guglielmo LuccheseDarja Kanduc
Mar 21, 2012·Immunopharmacology and Immunotoxicology·G Lucchese, A Pesce Delfino
Jan 21, 2016·Journal of Biomedical Science·Chien-Hsun WuHan-Chung Wu
Jul 10, 2012·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Stephanie N ShishidoSherry D Fleming
Jul 14, 2009·Peptides·Anthony KusalikDarja Kanduc
Dec 27, 2008·Experimental and Molecular Pathology·Angela Stufano, Darja Kanduc
Sep 18, 2004·The Journal of Investigative Dermatology·Abraham MittelmanDarja Kanduc
Feb 26, 2008·Autoimmunity Reviews·Darja KanducYehuda Shoenfeld
Apr 7, 2007·Autoimmunity Reviews·Darja KanducAbraham Mittelman
Jun 11, 2005·Experimental Dermatology·Jörg WillersDarja Kanduc
May 21, 2013·Journal of Basic Microbiology·Darja KanducGiovanni Capone
Mar 13, 2014·Journal of Ovarian Research·Piotr BodzekAleksandra Damasiewicz-Bodzek
Aug 4, 2009·Gynecologic Oncology·Douglas D TaylorLynn P Parker
May 26, 2018·Current Drug Discovery Technologies·Darja Kanduc
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alberta LuccheseReinhard Dummer
Apr 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena N KlyushnenkovaRichard B Alexander

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.