Non-senescent Hydra tolerates severe disturbances in the nuclear lamina

Aging
Alexander V KlimovichThomas C G Bosch

Abstract

The cnidarian Hydra is known for its unlimited lifespan and non-senescence, due to the indefinite self-renewal capacity of its stem cells. While proteins of the Lamin family are recognized as critical factors affecting senescence and longevity in human and mice, their putative role in the extreme longevity and non-senescence in long-living animals remains unknown. Here we analyze the role of a single lamin protein in non-senescence of Hydra. We demonstrate that proliferation of stem cells in Hydra is robust against the disturbance of Lamin expression and localization. While Lamin is indispensable for Hydra, the stem cells tolerate overexpression, downregulation and mislocalization of Lamin, and disturbances in the nuclear envelope structure. This extraordinary robustness may underlie the indefinite self-renewal capacity of stem cells and the non-senescence of Hydra. A relatively low complexity of the nuclear envelope architecture in basal Metazoa might allow for their extreme lifespans, while an increasing complexity of the nuclear architecture in bilaterians resulted in restricted lifespans.

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Citations

Jul 31, 2020·Proceedings of the National Academy of Sciences of the United States of America·Maria BroounHelen McNeill
Jun 5, 2019·Nature Protocols·Alexander KlimovichThomas C G Bosch
Nov 5, 2019·Development·Matthias C VoggCharisios D Tsiairis
Jul 11, 2020·Proceedings of the National Academy of Sciences of the United States of America·Alexander KlimovichThomas C G Bosch
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jan TaubenheimSebastian Fraune
Oct 10, 2020·Cellular and Molecular Life Sciences : CMLS·Justyna Mikuła-PietrasikKrzysztof Książek
May 28, 2021·Frontiers in Cell and Developmental Biology·Anirudh PillaiSanjeev Galande
Jun 4, 2021·Frontiers in Molecular Biosciences·Susanne HoltzeArne Sahm

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Datasets Mentioned

BETA
AAH06551
AAC31544
CAB41015

Methods Mentioned

BETA
Transfection
Transmission electron microscopy
Electron microscopy
transgenic
gene knock-down
PCR

Software Mentioned

MEGA6
BLAST
ClustalW
HyLMN

Related Concepts

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