Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond

The Lancet Oncology
Sarita DubeyAnne M Traynor

Abstract

Early screening, adjuvant and sequential systemic treatment, and hormonal therapy have benefits in treatment of breast cancer. Management of non-small-cell lung cancer (NSCLC) is progressing and will hopefully follow in the same footsteps as that of breast cancer. Only recently have clinical trials established adjuvant treatment as the standard of care in lung cancer. A growing number of effective cytotoxic and targeted agents have resulted in increased survival when used as sequential treatment in both breast cancer and NSCLC. The interaction between oestrogen receptors (ER) in the lung and epidermal growth factor receptor (EGFR) suggests a potential role for endocrine manipulation in the treatment of NSCLC. This complex interaction involves several types of ER receptors and different signalling pathways. Interactions between tobacco and oestrogen confound the effects of exogenous oestrogens on risk of lung cancer, but not on that of breast cancer. The optimum application of hormonal manipulation to prevent or treat lung cancer will depend on a more-complete understanding of lung-specific ER signalling. Early trials have assessed the interaction between the ER and EGFR signalling.

References

Feb 19, 1976·The New England Journal of Medicine·G BonadonnaU Veronesi
Apr 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J D Croxtall, R J Flower
Feb 23, 1989·The New England Journal of Medicine·E G MansourG Falkson
Dec 21, 1988·Journal of the National Cancer Institute·E Aboud-PirakM Sela
Jul 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·C H BeattyR M Brenner
Jun 1, 1994·Journal of the National Cancer Institute·E Taioli, E L Wynder
Jul 29, 1996·International Journal of Cancer. Journal International Du Cancer·U KaiserK Havemann
Nov 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E G MansourG Falkson
Aug 30, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Y ChenJ Whang-Peng
Nov 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M NabholtzM von Euler
Apr 3, 2001·European Journal of Clinical Investigation·E Falkenstein, M Wehling
Apr 18, 2001·The Oncologist·F J EstevaG N Hortobagyi
Jul 11, 2001·Biochemical and Biophysical Research Communications·Y OmotoS I Hayashi
Jul 17, 2001·Journal of Cellular Biochemistry. Supplement·R I YardenS A Chrysogelos
Dec 4, 2001·Trends in Pharmacological Sciences·A NadalB Soria
Jan 11, 2002·The New England Journal of Medicine·Joan H SchillerUNKNOWN Eastern Cooperative Oncology Group
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 26, 2002·Molecular and Cellular Endocrinology·Michael J FascoSimon D Spivack
Jun 18, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joyce O'ShaughnessyRobert Leonard
Jul 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Steen MollerupAage Haugen
Nov 8, 2002·The Journal of Biological Chemistry·Mahnaz RazandiEllis R Levin
Dec 5, 2002·Pharmacoepidemiology and Drug Safety·Janine A BlackmanSamuel Shapiro
Jul 3, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Frank FossellaChandra P Belani
Jul 31, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M NabholtzB Thürlimann
Nov 13, 2003·Molecular and Cellular Biology·Cesare PatroneMagnus Nord
Jan 7, 2004·Nature Reviews. Drug Discovery·Anthony W NormanDerek P G Norman
Jan 13, 2004·Menopause : the Journal of the North American Menopause Society·László B Tankó, Claus Christiansen
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew B SchabathMargaret R Spitz
Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Mar 12, 2004·The New England Journal of Medicine·R Charles CoombesUNKNOWN Intergroup Exemestane Study
Apr 15, 2004·JAMA : the Journal of the American Medical Association·Jyoti D PatelMark G Kris
Apr 23, 2004·The New England Journal of Medicine·Harubumi KatoUNKNOWN Japan Lung Cancer Research Group on Postsurgical Adjuvant Chemotherapy

❮ Previous
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Citations

Sep 30, 2010·Breast Cancer Research and Treatment·Christine BouchardyElisabetta Rapiti
Sep 21, 2007·Nature Reviews. Cancer·Sophie SunAdi F Gazdar
Jun 27, 2009·American Journal of Respiratory Cell and Molecular Biology·Margarita M IvanovaCarolyn M Klinge
Jan 1, 2013·BMC Cancer·Venkatakrishna Rao JalaCarolyn M Klinge
Nov 26, 2009·Molecular Cancer·Angelos KoutrasHaralabos Kalofonos
May 8, 2013·Lung Cancer Management·Nadiyah KazmiRichard J Pietras
Jul 20, 2007·Taiwanese Journal of Obstetrics & Gynecology·Wen-Hung KuoFon-Jou Hsieh
Dec 10, 2009·Seminars in Oncology·David PlanchardJean-Charles Soria
Oct 24, 2014·Cancer Science·Li-Han HsuShu-Huei Kao
Jan 26, 2011·Cancer·Christine BouchardyElisabetta Rapiti
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Geoffrey C KabatThomas E Rohan
Dec 24, 2014·Scientific Reports·Jun Ho YiJeeyun Lee
May 12, 2017·Cancer Biology & Therapy·Shin SaitoHarmik J Soukiasian
Jun 30, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ralf G MeyerRoland Buhl
Jan 1, 2012·Cancers·Christina S Baik, Keith D Eaton
Aug 8, 2017·International Journal of Molecular Sciences·Li-Han HsuShu-Huei Kao
Jun 28, 2007·International Journal of Cancer. Journal International Du Cancer·Zsuzsa RákosyMargit Balázs
Jan 15, 2010·The American Journal of Clinical Nutrition·Taichi ShimazuUNKNOWN Japan Public Health Center-based Prospective Study Group
Feb 29, 2020·Journal of Cancer Research and Clinical Oncology·Ying-Yi ChenTsai-Wang Huang
Mar 17, 2007·The Journal of Biological Chemistry·Keishi NaritaViji Shridhar
Jun 24, 2008·The Journal of Nutrition·Daniela GalloGiovanni Scambia
Aug 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J Pietras, Diana C Márquez-Garbán
Feb 6, 2007·Steroids·Diana C Márquez-GarbánRichard J Pietras
Nov 23, 2007·Revue des maladies respiratoires·J MazièresL Brouchet

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