Non-small cell lung cancer patients with brain metastases treated with first-line platinum-doublet chemotherapy: Analysis from the European FRAME study

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Denis Moro-SibilotPhilipp A Schnabel

Abstract

We report on a post-hoc analysis of patients with brain metastases from a large prospective observational study of first-line treatment of non-small cell lung cancer (NSCLC). The aim was to describe baseline characteristics of NSCLC patients with brain metastases, understand their first-line treatment and report outcomes attained in real-world settings. This post-hoc analysis included all patients in the European observational FRAME study who had brain metastases at initiation of first-line treatment. Descriptive statistics were used for continuous and categorical variables and survival outcomes were assessed using the Kaplan-Meier approach. Our data showed that 17% of patients (263/1564) had spread of the disease to the brain at initiation of first-line treatment. Patients with brain metastases were slightly younger, and more likely to have NSCLC of non-squamous histology than the overall study sample. 34% had received prior palliative radiotherapy to the brain. Our analysis showed a median overall survival (OS) of 7.2 months [95% confidence interval (CI) 6.1-8.2] for all patients with brain metastases treated with first-line platinum-based chemotherapy, ranging from 5.6 months for those treated with gemcitabine plus platinum ...Continue Reading

References

Dec 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul W SperdutoMinesh Mehta
Oct 9, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Philipp A SchnabelDenis Moro-Sibilot
Aug 15, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M ReckUNKNOWN ESMO Guidelines Working Group
Jan 24, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benjamin BesseJean-Charles Soria
Mar 10, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Denis Moro-SibilotPhilipp A Schnabel

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Citations

Aug 14, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jin-Feng TengAn-Guo Wu
Jan 7, 2017·Current Opinion in Oncology·Jordi Remon, Benjamin Besse
Aug 29, 2021·Critical Reviews in Oncology/hematology·Janna Josephus Anna Oda SchoenmaekersLizza Elisabeth Lucia Hendriks
Dec 22, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael A VogelbaumDavid Schiff

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