Non-small cell lung cancer transdifferentiation into small cell lung cancer: A case series

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Tahreem AhmedHoriana B Grosu

Abstract

Transdifferentiation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) has been reported mostly in adenocarcinomas and has been described as a cause of acquired tyrosine kinase inhibitor (TKI) resistance. However, transdifferentiation has also been described in patients with different histologic characteristics and patients not exposed to TKIs and with no epidermal growth factor receptor (EGFR) mutation (the target of TKIs). To this date transdifferentiation remains poorly understood. We conducted a retrospective case series of patients who had biopsy-proven SCLC within 2 years after a diagnosis of NSCLC or in the same location as the known primary NSCLC. We found that 0.2% of lung cancer patients at our institution experienced transdifferentiation. Among these, 30 had adenocarcinoma and 16 had squamous cell carcinoma. In 27 of the 30 patients with adenocarcinoma (90%), SCLC was found in the same location as the known primary. In 14 of the 30 patients (47%), SCLC occurred within 2 years after the NSCLC diagnosis. In 12 of the 16 patients with squamous cell carcinoma (75%), SCLC was found in the same location as the known primary. In 8 of these 16 patients (50%), SCLC occurred within 2 years after the NSCL...Continue Reading

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Citations

May 3, 2019·Journal of Pathology and Translational Medicine·Hyojin Kim, Jin-Haeng Chung
Sep 28, 2018·International Journal of Cancer. Journal International Du Cancer·Danwen QianQingyi Wei
Nov 13, 2018·Journal of Cancer Research and Clinical Oncology·Tingting GuoPeng Gao
Oct 2, 2019·Cancer Communications·Yueqing ChenHongbin Ji
Apr 27, 2021·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Yuting ChenHongbin Ji

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