Non-small-cell lung cancer: what are the benefits and challenges of treating it with immune checkpoint inhibitors?

Immunotherapy
Elie RassyBenjamin Besse

Abstract

Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of advanced non-small-cell lung cancer (NSCLC). It has improved the overall survival in the first- and second-line setting with manageable adverse events. Multiple challenges still impede the success of ICI in the whole population of NSCLC namely the lack of reliable predictive biomarkers, the scarcity of data regarding the optimal treatment duration with ICI and possibility of rechallenge with ICI as well as the efficacy of ICI in special subgroups of patients such as those with oncogenic addicted tumors or patients with brain metastases. In this framework, we review the benefits and challenges of ICI in NSCLC, in monotherapy and in combinations, in the advanced setting.

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Citations

Aug 12, 2020·Expert Review of Anticancer Therapy·Elie Rassy, Nicholas Pavlidis
Jan 18, 2020·Journal of Cancer Survivorship : Research and Practice·Rebekah ParkJacob McAuliffe
Jan 5, 2021·Expert Opinion on Drug Safety·Pamela Abdayem, David Planchard
Feb 28, 2020·Critical Reviews in Oncology/hematology·Elie RassyNicholas Pavlidis
May 11, 2021·European Journal of Clinical Investigation·Elie RassyNicholas Pavlidis

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Methods Mentioned

BETA
exome sequencing
biopsy

Clinical Trials Mentioned

NCT01285609
NCT02869789
NCT03215706
NCT03469960
NCT02542293
NCT03164616

Software Mentioned

iRECIST
irRECIST

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