Non-specific effects of vaccines: plausible and potentially important, but implications uncertain

Archives of Disease in Childhood
Andrew J PollardNigel Curtis

Abstract

Non-specific effects (NSE) or heterologous effects of vaccines are proposed to explain observations in some studies that certain vaccines have an impact beyond the direct protection against infection with the specific pathogen for which the vaccines were designed. The importance and implications of such effects remain controversial. There are several known immunological mechanisms which could lead to NSE, since it is widely recognised that the generation of specific immunity is initiated by non-specific innate immune mechanisms that may also have wider effects on adaptive immune function. However, there are no published studies that demonstrate a mechanistic link between such immunological phenomena and clinically relevant NSE in humans. While it is highly plausible that some vaccines do have NSE, their magnitude and duration, and thus importance, remain uncertain. Although the WHO recently concluded that current evidence does not justify changes to immunisation policy, further studies of sufficient size and quality are needed to assess the importance of NSE for all-cause mortality. This could provide insights into vaccine immunobiology with important implications for infant health and survival.

Citations

Feb 8, 2018·The Journal of Infectious Diseases·Bridget FreyneNigel Curtis
Nov 28, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ane B FiskerPeter Aaby
Nov 24, 2017·Scientific Reports·Mostafa Ebraheem MorraNguyen Tien Huy
Nov 11, 2017·Seminars in Immunopathology·Anja Saso, Beate Kampmann
Jun 9, 2018·Expert Review of Vaccines·Petra Zimmermann, Nigel Curtis
Jan 15, 2019·The Pediatric Infectious Disease Journal·Nigel Curtis
Jun 4, 2019·Human Vaccines & Immunotherapeutics·Federico Martinón-TorresRobb Butler
Feb 8, 2020·The Pediatric Infectious Disease Journal·Sophia R NewcomerJason M Glanz
Jan 10, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Samantha BannisterNigel Curtis
Jan 29, 2020·The Journal of Infectious Diseases·Bridget FreyneUNKNOWN Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR) Group
Aug 9, 2020·Human Vaccines & Immunotherapeutics·Vipin M Vashishtha
Sep 17, 2020·Rheumatology International·Ummusen Kaya AkcaSeza Ozen
Aug 28, 2020·Frontiers in Microbiology·Anja Saso, Beate Kampmann
Sep 17, 2020·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Radu Crisan-DabijaAlexandru Burlacu
May 5, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Sara SorgiEduardo L V Silveira
Dec 30, 2020·Vaccine·Laure F PittetUNKNOWN BCG Immune Response Study (BIRS) group
Sep 26, 2020·Reviews in Medical Virology·Laure F Pittet, Nigel Curtis
Feb 12, 2021·GeroScience·Jennifer ConnorsElias K Haddad
Dec 24, 2020·Nature Reviews. Immunology·Andrew J Pollard, Else M Bijker
Nov 17, 2020·Frontiers in Public Health·Bojana Beric-StojsicSanjoy Roy
Oct 5, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Lise GehrtSigne Sørup
Apr 1, 2021·BMC Urology·Héctor GallegosIgnacio F San Francisco
Apr 2, 2021·Infection and Drug Resistance·Gopala KoneruHelal F Hetta
Jul 13, 2020·Paediatric Respiratory Reviews·Archana KoiralaPhilip N Britton
Apr 4, 2021·Vaccine·Samantha BannisterNigel Curtis
Sep 12, 2021·Vaccine·Josephine A P van DongenUNKNOWN RIVAR study team
Oct 13, 2021·The Pediatric Infectious Disease Journal·Paola VillanuevaNigel Curtis
May 26, 2018·Pediatrics·Nadja Hawwa VissingHans Bisgaard

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