PMID: 44360Dec 1, 1979

Non-specific induction of increased resistance in mice to Trypanosoma congolense and Trypanosoma brucei by immunostimulants

Parasitology
M Murray, W I Morrison

Abstract

Administration of the immunostimulants Corynebacterium parvum, Bacillus Calmette-Guérin (BCG) or Bordetella pertussis prior to, or at the same time as, challenge with Trypanosoma congolense significantly increased survival times in mice, both of trypano-susceptible (A/J) and trypano-resistant (C57Bl) strains. The increased survival time was associated with significant alterations in parasitaemia, which included lengthening of the pre-patent period, a delay in the time taken to reach the first peak of parasitaemia and a reduction in the level of parasitaemia. Similar results were obtained when these strains of mice were challenged with Trypanosoma brucei following pre-treatment with C. parvum. Thus, by the use of immunostimulants it was possible to reduce the susceptibility of mice to trypanosomiasis and the hope is that this can also be achieved with domestic livestock.

References

Feb 1, 1977·The Journal of Pharmacy and Pharmacology·P I Akubue
Jan 1, 1977·Advances in Experimental Medicine and Biology·M Murray, G M Urquhart
Jan 1, 1977·Advances in Experimental Medicine and Biology·J J Doyle
Oct 2, 1975·Nature·Y KressH Tanowitz
Jan 27, 1977·Nature·D W Brocklesby, R E Purnell
Apr 1, 1977·Infection and Immunity·L L Smrkovski, C L Larson
Nov 1, 1975·L'Infirmière francaise·J Meerschart
Jul 24, 1975·Nature·M E Rau, C E Tanner
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Citations

Dec 13, 2000·Microbes and Infection·H TabelJ E Uzonna
Jan 27, 2009·Infection and Immunity·Nicolas Antoine-MoussiauxDaniel Desmecht
Feb 1, 1987·International Journal for Parasitology·F E Cox
Nov 1, 1992·Experimental Parasitology·Philippe VincendeauJ L Lemesre
Dec 5, 2006·Anais Da Academia Brasileira De Ciências·Philippe Vincendeau, Bernard Bouteille
Sep 1, 1982·Parasite Immunology·A FerranteH Hirumi
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B A Askonas, G J Bancroft
Jan 14, 2017·Frontiers in Microbiology·Alicia Ponte-Sucre

Related Concepts

Antigens
Blood
Bordetella pertussis Bacterium
Corynebacterium
Mice, Inbred Strains
Mycobacterium bovis
Nannomonas
Trypanosoma brucei brucei
Nagana

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