Non-specific interstitial pneumonia as the initial presentation of biphenotypic acute leukemia: a case report.

Cases Journal
Arun V MohanEyal C Attar

Abstract

Nonspecific interstitial pneumonia has been linked to numerous etiologies including, most recently, haematologic malignancy. We present a 46-year-old woman with recent-onset rheumatologic illness who developed pulmonary symptoms as the presenting feature of biphenotypic acute leukaemia. Chest radiology demonstrated bilateral infiltrates, and lung biopsy revealed nonspecific interstitial pneumonia. Corticosteroid therapy resulted in resolution of both her pulmonary and rheumatologic symptoms, and her pulmonary symptoms did not recur following treatment of her leukemia. The case highlights the importance of searching for an underlying etiology when confronted with nonspecific interstitial pneumonia.

References

Feb 24, 2001·Journal of the American Academy of Dermatology·M AsaiT Tezukam
Jan 21, 2003·Leukemia & Lymphoma·Muhammad Wasif SaifSteven D Gore
Oct 8, 2004·Internal Medicine·Toshio SatoToshihiko Ishida
Mar 9, 2005·Respiration; International Review of Thoracic Diseases·Hiroshi IshiiShigeru Kohno
Dec 30, 2006·Seminars in Respiratory and Critical Care Medicine·Kevin R Flaherty, Fernando J Martinez
Mar 30, 2007·Critical Reviews in Oncology/hematology·Martin SternCatherine Nissen-Druey
Jun 27, 2007·British Journal of Haematology·Ahmed AribiFarhad Ravandi
Apr 5, 2008·American Journal of Respiratory and Critical Care Medicine·William D TravisAthol Wells

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Methods Mentioned

BETA
X-ray
bronchoalveolar lavage
biopsy
bone marrow aspiration

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